Stereotactic Ablative Radiotherapy for stage I histologically proven non-small cell lung cancer: An Italian multicenter observational study

Ricardi, Umberto; Frezza, G.P.; Filippi, Andrea Riccardo; Badellino, Serena; Levis, Mario; Navarria, Pierina; Salvi, Fabrizio; Marcenaro, Michela; Trovò, Marco; Guarneri, Alessia; Corvò, Renzo; Scorsetti, Marta

doi:10.1016/j.lungcan.2014.02.015

Cited by 68 publications

(41 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This recommendation is based on the results of several prospective phase II trials [2], [3], [4], [5] and [6], as well as large observational studies [7], [8] and [9], with variable follow-up intervals: most of them were limited to spirometric parameters and diffusing capacity for carbon monoxide (Diffusion Lung capacity for Carbon monoxide, D L CO). Recently, a more comprehensive analysis of "complete" Pulmonary Function Tests (including blood gas analysis) was reported, on a series of patients enrolled in the RTOG 0236 phase II trial of SABR in inoperable patients [10].…”

Section: Introductionmentioning

confidence: 99%

Pulmonary function and quality of life after VMAT-based stereotactic ablative radiotherapy for early stage inoperable NSCLC: a prospective study

Badellino

Filippi

et al. 2015

Lung Cancer

Self Cite

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Pulmonary function and quality of life after VMAT-based stereotactic ablative radiotherapy for early stage inoperable NSCLC: a prospective study

Badellino

Filippi

et al. 2015

Lung Cancer

Self Cite

View full text Add to dashboard Cite

“…However, the cut-off was difficult to determine. Several studies suggested that a bed cut-off of approximately 100 is significantly correlated with patient outcome 17,[19][20][21][22]26 ; however, other studies, including the meta-regression by Zhang et al, did not show that association 18,24,25,27,29 .…”

Section: Key Evidencementioning

confidence: 98%

“…Twelve retrospective observational studies investigated the most appropriate bed cut-off in association with patient outcomes [17][18][19][20][21][22][23][24][25][26][27][28] . Again, the studies were considered to be very low quality because of their retrospective design.…”

Section: Key Evidencementioning

confidence: 99%

Guideline for Radiotherapy with Curative Intent in Patients with Early-Stage Medically Inoperable Non-Small-Cell Lung Cancer

Falkson

Vella

et al. 2017

Current Oncology

View full text Add to dashboard Cite

Objectives For this guideline, we investigated the effectiveness of radiotherapy with curative intent in medically inoperable patients with early-stage non-small-cell lung cancer (nsclc). MethodsThe guideline was developed by Cancer Care Ontario's Program in Evidence-Based Care and by the Lung Cancer Disease Site Group through a systematic review of mainly retrospective studies, expert consensus, and formal internal and external reviews. Recommendations■ Stereotactic body radiation therapy (sbrt) with curative intent is an option that should be considered for patients with early-stage, node-negative, medically inoperable nsclc. Qualifying Statements ■Because of the high dose per fraction, the planning process and treatment delivery for sbrt require the use of advanced technology to maintain an appropriate level of safety. Consistent patient positioning and 4-dimensional analysis of tumour and critical structure motion during simulation and treatment delivery are essential. ■Preliminary results for proton-beam therapy have been promising, but the technique requires further clinical study.■ Recommended fractionation schemes for sbrt should result in a biologically effective dose of 100 or greater by the linear quadric model, choosing an α/β value of 10 [bed 10(LQ) ≥ 100]. Qualifying Statements ■Because of the increased risk of treatment-related adverse events associated with centrally located tumours, consideration of tumour size and proximity to critical central structures is required when determining the dose and fractionation. ■Examples of dose-fractionation schemes used in the included studies have been provided. ■Based on the current evidence and the opinion of the authors, radiation doses at bed 10(LQ) greater than 146 might significantly increase toxicity and should be avoided. ■Determination of the radiation bed by the linear quadratic model has limitations for the extreme hypofractionated schemes used in sbrt.

show abstract

“…Stereotactic body radiotherapy (SBRT), with a 3-year local control rate of 80∼90%, has been suggested as an alternative treatment option in these patients. 1,2) In recent series, the results of SBRT were comparable or better than those for sublobar resection. [3][4][5] Several studies reported that higher biologically equivalent dose was related to improved local control and survival.…”

Section: Introductionmentioning

confidence: 98%

Feasibility and Efficacy of Adaptive Intensity Modulated Radiotherapy Planning according to Tumor Volume Change in Early Stage Non-small Cell Lung Cancer with Stereotactic Body Radiotherapy

2015

View full text Add to dashboard Cite

The purpose of this study is to evaluate efficacy and feasibility of adaptive radiotherapy according to tumor volume change (TVC) in early stage non-small cell lung cancer (NSCLC) using stereotactic body radiotherapy (SBRT). Twenty-two lesions previously treated with SBRT were selected. SBRT was usually performed with a total dose of 48 Gy or 60 Gy in four fractions with an interval of three to four days between treatments. For evaluation of TVC, gross tumor volume (GTV) was contoured on each cone-beam computed tomography (CBCT) image used for image guidance. Intensity modulated radiotherapy (IMRT) planning was performed in the first CBCT (CBCT1) using a baseline plan. For ART planning (ART), re-optimization was performed at 2 nd , 3 rd , and 4 th CBCTs (CBCT2, CBCT3, and CBCT4) using the same angle and constraint used for the baseline plan. The ART plan was compared with the non-ART plan, which generated copying of the baseline plan to other CBCTs. Average GTV volume was 10.7 cc. Average TVC was -1.5%, 7.3%, and -25.1% in CBCT2, CBCT3, and CBCT4 and the TVC after CBCT3 was significant (p＜0.05). However, the nine lesions were increased GTV in CBCT2. In the ART plan, V20 Gy, D1500 cc, and D1000 cc of lung were significantly decreased (p＜0.05), and V30 Gy and V32 Gy of the chest wall were also decreased (p＜0.05). While D min of planning target volume (PTV) decreased by 8.3% in the non-ART plan of CBCT2 compared with the baseline plan in lesions with increased tumor size (p=0.021), PTV coverage was not compromised in the ART plan. Based on this result, use of the ART plan may improve target coverage and OAR saving. Thus ART using CBCT should be considered in early stage NSCLC with SBRT.

show abstract

Stereotactic Ablative Radiotherapy for stage I histologically proven non-small cell lung cancer: An Italian multicenter observational study

Cited by 68 publications

References 25 publications

Pulmonary function and quality of life after VMAT-based stereotactic ablative radiotherapy for early stage inoperable NSCLC: a prospective study

Pulmonary function and quality of life after VMAT-based stereotactic ablative radiotherapy for early stage inoperable NSCLC: a prospective study

Guideline for Radiotherapy with Curative Intent in Patients with Early-Stage Medically Inoperable Non-Small-Cell Lung Cancer

Feasibility and Efficacy of Adaptive Intensity Modulated Radiotherapy Planning according to Tumor Volume Change in Early Stage Non-small Cell Lung Cancer with Stereotactic Body Radiotherapy

Contact Info

Product

Resources

About