Stereospecific antioxidant effects of ginsenoside Rg3 on oxidative stress induced by cyclophosphamide in mice

Wei, Xiaojie; Su, Fei; Su, Xiaoyan; Hu, Ting‐Jun; Hu, Songhua

doi:10.1016/j.fitote.2012.01.006

Cited by 96 publications

(73 citation statements)

References 44 publications

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“…It is reported that a common side effect of CP related anticancer treatments are cardiovascular toxicity and acute fatal cardiomyopathy observed with high dose of CP (200 mg/kg) (Sayed-Ahmed et al 2014). It has also been reported that 100 mg/kg CP given to the rats caused oxidative stress, increased MDA and NO level, decreased TAS level (Wei et al 2012). Motawi et al (2010) found that at higher doses of CP (200 mg/kg), there was heart damage as a result of the high oxidative stress, NO and MDA and decreased GSH and TAS levels.…”

Section: Resultsmentioning

confidence: 95%

Protective Effect of Carvacrol Against Oxidative Stress and Heart Injury in Cyclophosphamide-Induced Cardiotoxicity in Rat

Çetik

Ayhancı

Şahıntürk

2015

Braz. arch. biol. technol.

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Section: Resultsmentioning

confidence: 95%

Protective Effect of Carvacrol Against Oxidative Stress and Heart Injury in Cyclophosphamide-Induced Cardiotoxicity in Rat

Çetik

Ayhancı

Şahıntürk

2015

Braz. arch. biol. technol.

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“…Meyer is one of a diverse group of steroidal saponins with high pharmacological activity [16]. Stereospecific effects have been observed from this compound, with the 20(R) enantiomer, for instance, being more active as an antioxidant and in its promotion of the immune response [17, 18], and the 20(S) having a greater potential anti-diabetic activity [19]. While the 20(R) enantiomer of this compound is poorly soluble, the 20(S) enantiomer has a much higher solubility, thus making it more suitable for pharmaceutical development.…”

Section: Introductionmentioning

confidence: 99%

20(S)-Ginsenoside Rg3 is a novel inhibitor of autophagy and sensitizes hepatocellular carcinoma to doxorubicin

et al. 2014

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Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. High mortality from HCC is mainly due to widespread prevalence and the lack of effective treatment, since systemic chemotherapy is ineffective, while the targeted agent Sorafenib extends median survival only briefly. The steroidal saponin 20(S)-ginsenoside Rg3 from Panax ginseng C.A. Meyer is proposed to chemosensitize to various therapeutic drugs through an unknown mechanism. Since autophagy often serves as cell survival mechanism in cancer cells exposed to chemotherapeutic agents, we examined the ability of Rg3 to inhibit autophagy and chemosensitize HCC cell lines to doxorubicin in vitro. We show that Rg3 inhibits late stage autophagy, possibly through changes in gene expression. Doxorubicin-induced autophagy plays a protective role in HCC cells, and therefore Rg3 treatment synergizes with doxorubicin to kill HCC cell lines, but the combination is relatively nontoxic in normal liver cells. In addition, Rg3 was well-tolerated in mice and synergized with doxorubicin to inhibit tumor growth in HCC xenografts in vivo. Since novel in vivo inhibitors of autophagy are desirable for clinical use, we propose that Rg3 is such a compound, and that combination therapy with classical chemotherapeutic drugs may represent an effective therapeutic strategy for HCC treatment.

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“…O grupo que recebeu somente a ciclofosfamida apresentou níveis significativamente superiores de lipoperoxidação em tecido hepático (aproximadamente 230%). Wei et al 22 , em estudo com camundongos fêmeas com 35 dias de idade, utilizaram a ciclofosfamida como indutor de imunossupressão na dose única de 100 mg/kg de peso administrados via intraperitoneal. Após análises em tecidos de timo e baço, foi verificado aumento significativo dos níveis de TBARS.…”

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Impacto da suplementação de vitamina C sobre níveis de peroxidação lipídica e glutationa reduzida em tecido hepático de camundongos com imunossupressão induzida por ciclofosfamida

et al. 2016

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ObjetivoInvestigar os efeitos da vitamina C sobre níveis de peroxidação lipídica e glutationa reduzida em tecido hepático de camundongos imunossuprimidos por ciclofosfamida. MétodosO estudo foi realizado em camundongos Swiss, fêmeas, com 45 dias de idade, separados em quatro grupos com oito animais cada. Grupos: controle (água destilada), vitamina C (50 mg/kg), ciclofosfamida (100 + 150 mg/kg)

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Stereospecific antioxidant effects of ginsenoside Rg3 on oxidative stress induced by cyclophosphamide in mice

Cited by 96 publications

References 44 publications

Protective Effect of Carvacrol Against Oxidative Stress and Heart Injury in Cyclophosphamide-Induced Cardiotoxicity in Rat

Protective Effect of Carvacrol Against Oxidative Stress and Heart Injury in Cyclophosphamide-Induced Cardiotoxicity in Rat

20(S)-Ginsenoside Rg3 is a novel inhibitor of autophagy and sensitizes hepatocellular carcinoma to doxorubicin

Impacto da suplementação de vitamina C sobre níveis de peroxidação lipídica e glutationa reduzida em tecido hepático de camundongos com imunossupressão induzida por ciclofosfamida

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