2018
DOI: 10.1016/j.chroma.2018.07.075
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Stereoselectiveseparation of racemic trans-paroxol, N-methylparoxetine and paroxetine containing two chiral carbon centres by countercurrent chromatography

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Cited by 11 publications
(12 citation statements)
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“…Substituted β‐cyclodextrin is one of the most conspicuous and developmental potential chiral selectors due to its special stereoscopic structure and properties [27]. Hydroxypropyl‐β‐cyclodextrin, as the most widely used neutral β‐cyclodextrin, plays an important role in chiral countercurrent chromatography [20,22,23,28–33]. Limited number of literatures reported other substituted β‐cyclodextrins such as hydroxyethyl‐β‐cyclodextrin [21], carboxymethyl‐β‐cyclodextrin [24,34,35], sulfated‐β‐cyclodextrin [36,37], and methyl‐​β‐​cyclodextrin [38].…”
Section: Introductionmentioning
confidence: 99%
“…Substituted β‐cyclodextrin is one of the most conspicuous and developmental potential chiral selectors due to its special stereoscopic structure and properties [27]. Hydroxypropyl‐β‐cyclodextrin, as the most widely used neutral β‐cyclodextrin, plays an important role in chiral countercurrent chromatography [20,22,23,28–33]. Limited number of literatures reported other substituted β‐cyclodextrins such as hydroxyethyl‐β‐cyclodextrin [21], carboxymethyl‐β‐cyclodextrin [24,34,35], sulfated‐β‐cyclodextrin [36,37], and methyl‐​β‐​cyclodextrin [38].…”
Section: Introductionmentioning
confidence: 99%
“…Recycling elution mode was usually employed to improve enantioseparation in various chromatographic methods . In our very recent work, CCC was successfully applied for stereoselective separation of drugs and intermediates containing two chiral centers for the first time . In the present work, we want to report our recent work on stereoselective separation of four isomeric sertraline by an analytical countercurrent chromatographic apparatus designed in our lab, ( 1S, 4S ), ( 1R, 4R ), ( 1S, 4R ), and ( 1R, 4S )‐isomer, from the medicinal reaction mixture obtained during the synthesis of the antidepressant drug ( 1S, 4S )‐sertraline hydrochloride.…”
Section: Introductionmentioning
confidence: 99%
“…F I G U R E 1 Stereochemical structures of acetyltropic acid enantiomer of studies are available, which are about enantioseparations by CCC [16][17][18][19][20]. To the best of our knowledge, only two papers have been published so far with regard to enantioseparation by CCC using sulfobutyl ether-β-cyclodextrin as chiral selector [26,27], although many papers have been published for enantioseparation by liquid-liquid partition chromatography using hydroxypropyl-β-cyclodextrin and other substituted β-cyclodextrin as chiral selectors [16][17][18][19][20][22][23][24]. At the same time, it is difficult to find a biphasic solvent system along with a chiral selector showing high enantiorecognition toward enantiomer, in which the chiral selector should be predominantly dissolved in only one phase of the biphasic solvent system while the racemate to be enantioseparated can partition freely in both phases.…”
Section: Introductionmentioning
confidence: 99%
“…CCC is a liquid-liquid partition chromatography that has been widely used for preparative separation of active component from natural product [13], synthetic mixture [14], and fermentation broth [15]. However, only very limited numbers F I G U R E 1 Stereochemical structures of acetyltropic acid enantiomer of studies are available, which are about enantioseparations by CCC [16][17][18][19][20]. The number of theoretical plates of the separation column of CCC being much lower than that of conventional LC makes it difficult to be successfully applied in enantioseparations.…”
Section: Introductionmentioning
confidence: 99%
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