Stereoselective Total Synthesis of Macrolide Sch-725674 and C-7-epi-Sch-725674

Baikadi, Karunakar; Talakokkula, Anil; Narsaiah, A. Venkat

doi:10.1055/s-0037-1611665

Cited by 3 publications

(1 citation statement)

References 12 publications

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“…The stereoselective synthesis of Sch‐725674 11 , a macrolide, utilizing Julia‐Kocienski olefination was reported by Narsalah and co‐workers [10] (Scheme 2). This compound was obtained from Aspergillus sp culture.In 2005, Yang et al .…”

Section: Applications Of Julia‐kocienski Olefination In Natural Produ...mentioning

confidence: 97%

Recent Applications and Trends in the Julia‐Kocienski Olefination

Rinu¹,

Radhika²,

Anilkumar³

2022

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The Julia-Kocienski (J-K) olefination is a modified version of Julia-Lythgoe olefination. In this reaction, an aldehyde or ketone is coupled with heterocycle-bearing sulfone in the presence of a strong base to yield alkene. It has shown wide application in the synthesis of olefinic fragments in natural product synthesis. The Julia-Kocienski olefination is one of the most efficient protocols for the synthesis of E-alkenes. Nowa-days, a variety of natural products were synthesised by using the Julia-Kocienski olefination as the key step, and several developments and modifications were witnessed in this area. This review comprehends the recent developments and achievements in Julia-Kocienski olefination along with its application in natural product synthesis covering literature from 2016 to 2021.

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Section: Applications Of Julia‐kocienski Olefination In Natural Produ...mentioning

confidence: 97%

Recent Applications and Trends in the Julia‐Kocienski Olefination

Rinu¹,

Radhika²,

Anilkumar³

2022

ChemistrySelect

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Studies Towards the Stereoselective Total Synthesis of 7‐O‐methylnigrosporolide

2019

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The first synthetic approach towards the cytotoxic agent, 7‐O‐methylnigrosporolide is described in 13 linear steps with 10.5% overall yield. The synthesis started from commercially available starting materials, D‐mannitol and 5‐hexenol. The key features of the synthetic pathway involved are Hydrolytic Kinetic Resolution, C2‐Wittig, CBS reduction, Horner‐Wadsworth‐Emmons reaction, Shiina macrolacto‐nization and Lindlar reduction.

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Total synthesis of natural alkaloids Schwarzinicines A-D

Annapurna,

Venkat Narsaiah

2024

Tetrahedron

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Stereoselective Total Synthesis of Macrolide Sch-725674 and C-7-epi-Sch-725674

Cited by 3 publications

References 12 publications

Recent Applications and Trends in the Julia‐Kocienski Olefination

Recent Applications and Trends in the Julia‐Kocienski Olefination

Studies Towards the Stereoselective Total Synthesis of 7‐O‐methylnigrosporolide

Total synthesis of natural alkaloids Schwarzinicines A-D

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