Abstract:The combination of small molecule catalysis and enzyme catalysis represents an underexploited area of research with huge potential in asymmetric synthetic chemistry due to both compatibility in reaction conditions and complementary reactivity. In this manuscript, we describe the telescopic synthesis of chiral nitro alcohols starting from commercially available benzaldehyde derivatives via the one-pot three-step chemoenzymatic cascade combination of a Wittig reaction, chiral thiourea-catalysed asymmetric conjug… Show more
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