Stereoselective synthesis of spirocyclic pyrrolidines/pyrrolizidines/pyrrolothiazolidines using l-proline functionalized manganese ferrite nanorods as a novel heterogeneous catalyst

Abstract

An efficient, green, one-pot, and three-component protocol has been reported for the stereoselective synthesis of a new class of spiro thiazolidines.

Catalyst-Free, Room-Temperature Accessible Regioselective Synthesis of Spiroquinolines and Their Antioxidant Study

“…The S41). 46 In COSY NMR analysis of compound 4b, it shows that H-18 is correlated with H-16, H-20, and H-24′ (Figure S42).…”

“…In addition, other characteristic peaks were found at δ 133.16, 131.11, 129.56, 129.35, 129.12, 128.91, 97.78, and 107.99 which correlate to aromatic carbons ( Figure S41 ). 47 In COSY NMR analysis of compound 4b , it shows that H-18 is correlated with H-16, H-20, and H-24′ ( Figure S42 ).…”

Contemporary progress in the green synthesis of spiro-thiazolidines and their medicinal significance: a review

“…l -Proline MNR-supported catalyzed, effectual, one-pot, green, and three-component approach was investigated by A. Bekhradnia and his group 75 for the stereoselective construction of a novel class of spirothiazolidine derivatives. The interaction of 5-arylidene thiazolidine-2,4-diones ( 43 ), isatin ( 40 ), and secondary amino acids ( 41a–c ) with MCCFe 2 O 4 @ l -proline (MnCoCuFe 2 O 4 @ l -proline) magnetic nanorods as a new nanocatalyst yielded a series of spiro-heterocycle derivatives ( 44a–c ) stereoselectively and in high yields (Scheme 14).…”

Green synthesis, anti-proliferative evaluation, docking, and MD simulations studies of novel 2-piperazinyl quinoxaline derivatives using hercynite sulfaguanidine-SA as a highly efficient and reusable nanocatalyst

“…Finally, followed preparation of 2-piperazinyl quinoxaline ( I ) with piperazine in toluene, the desired final products (2-piperazinyl quinoxaline derivatives) were produced in a novel and one-step method in the presence of nanocatalyst FeAl 2 O 4 @PTMS-sulfaguanidine-SA MNPs (40 mg). 16 Schemes 2–4 illustrated the general synthesis pathway of compounds 2a–2d , 3a–3h , and 4a–4d (series A, B, and C respectively) from the main initial substrate 2-piperazinyl quinoxaline (compound I ). The structures of the final products were confirmed by the elemental and spectral analyses which the corresponding results are available within the related article 15–17 or the ESI (Fig.…”

“…16 Schemes 2–4 illustrated the general synthesis pathway of compounds 2a–2d , 3a–3h , and 4a–4d (series A, B, and C respectively) from the main initial substrate 2-piperazinyl quinoxaline (compound I ). The structures of the final products were confirmed by the elemental and spectral analyses which the corresponding results are available within the related article 15–17 or the ESI (Fig. S1) †…”