Abstract:(E)- and (Z)-isocyanoalkenes
were selectively synthesized via the sequential cross coupling of
vinyl iodides with formamide, followed by dehydration. The optimal
catalyst, generated in situ from CuII and trans-N,N′-dimethyl-1,2-cyclohexanediamine, rapidly coupled (E)- or (Z)-vinyl iodides with formamide, which minimized
the isomerization of the resultant vinyl formamide. The method efficiently
provided a range of acyclic, carbocyclic, and heterocyclic isocyanoalkenes;
the versatility is illustrated with the se… Show more
We report a Cu(i)-catalyzed synthesis of quinazolines via cascade cyclization/hydrodehalogenation by using acetamide as a nitrogen source and H2O as a hydrogen source.
We report a Cu(i)-catalyzed synthesis of quinazolines via cascade cyclization/hydrodehalogenation by using acetamide as a nitrogen source and H2O as a hydrogen source.
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