Stereoselective synthesis of dihydrothiadiazinoazines and dihydrothiadiazinoazoles and their pyrolytic desulfurization ring contraction

Al-Etaibi, Alya M.; John, Elizabeth; Ibrahim, Maher R.; Al‐Awadi, Nouria A.; Ibrahim, Yehia A.

doi:10.1016/j.tet.2011.06.034

Cited by 30 publications

(16 citation statements)

References 17 publications

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“…Interestingly, significant influence of the solvents on isomeric ratio of compound 7d was not detected, in contrast to the work in that have reported cyclocondensation of 1‐benzyldeneamino‐5‐mercapto‐1,3,4‐triazoles with α‐bromoacetophenones giving dihydro triazolothiadiazines.…”

Section: Resultscontrasting

confidence: 84%

Transformation of 1,2,3‐Thiadiazolyl Hydrazones as Method for Preparation of 1,2,3‐Triazolo[5,1‐b][1,3,4]thiadiazines

Калинина

Bystrykh

Глухарева

et al. 2015

Journal of Heterocyclic Chem

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The transformation of 1,2,3‐thiadiazolyl hydrazones of aldehydes and ketones including Dimroth rearrangement giving 1‐alkylidenamino‐5‐mercapto‐1,2,3‐triazoles, alkylation of mercapto group of these heterocyclic compounds by α‐bromoacetophenones and cyclization giving 6,7‐dihydro‐5H‐[1,2,3]triazolo[5,1‐b][1,3,4]thiadizines have been investigated. It was shown that the reaction for hydrazones of acetophenones and benzoaldehydes is diastereoselective. Triazolothiadiazine spiro derivatives were prepared with transformation of hydrazones of cyclic ketones.

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Section: Resultscontrasting

confidence: 84%

Transformation of 1,2,3‐Thiadiazolyl Hydrazones as Method for Preparation of 1,2,3‐Triazolo[5,1‐b][1,3,4]thiadiazines

Калинина

Bystrykh

Глухарева

et al. 2015

Journal of Heterocyclic Chem

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“…Known ( 1 – 6 ) and previously unreported intermediates ( 7 – 11 ) and their precursors were synthesized according to established methods . 2‐(3‐Bromobutoxy)isoindoline‐1,3‐dione ( 12 ) and 2‐(3‐oxobutoxy)isoindoline‐1,3‐dione ( 19 ) were prepared as previously described . Compound 12 was converted into the corresponding alkyliodide 13 by Finkelstein reaction with sodium iodide in acetone.…”

Section: Resultsmentioning

confidence: 58%

8‐Aminoquinolines with an Aminoxyalkyl Side Chain Exert in vitro Dual‐Stage Antiplasmodial Activity

et al. 2019

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A series of novel 8‐aminoquinolines (8‐AQs) with an aminoxyalkyl side chain were synthesized and evaluated for in vitro antiplasmodial properties against asexual blood stages, liver stages, and sexual stages of Plasmodium falciparum. 8‐AQs bearing 2‐alkoxy and 5‐phenoxy substituents on the quinoline ring system were found to be the most promising compounds under study, exhibiting potent blood schizontocidal and moderate tissue schizontocidal in vitro activity.

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“…The reaction of 4‐amino‐6‐benzyl‐3‐mercapto‐1,2,4‐triazin‐5(4 H )‐one ( 3 ) with various aldehydes under reflux in ethanol in the presence either of conc. H 2 SO 4 and/or conc.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Acaricidal Activity of Some New 1,2,4‐Triazine Derivatives

Hamama

El‐Bana

Mostafa

et al. 2018

Journal of Heterocyclic Chem

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A new series of 1,2,4‐triazine derivatives were designed, synthesized, and identified on the basis of IR, 1H‐NMR, 13C‐NMR, and EI‐MS spectral data. The potent acaricidal activity of 1,2,4‐triazine derivatives against eggs and adult female of Tetranychus urticae (Koch) was assessed compared with pyridaben under laboratory conditions. Structure acaricidal activity relationships of the promising 1,2,4‐triazine derivatives were analyzed for eggs and adult female; the nature and position of the substituents were important in demonstration of the activities.

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Stereoselective synthesis of dihydrothiadiazinoazines and dihydrothiadiazinoazoles and their pyrolytic desulfurization ring contraction

Cited by 30 publications

References 17 publications

Transformation of 1,2,3‐Thiadiazolyl Hydrazones as Method for Preparation of 1,2,3‐Triazolo[5,1‐b][1,3,4]thiadiazines

Transformation of 1,2,3‐Thiadiazolyl Hydrazones as Method for Preparation of 1,2,3‐Triazolo[5,1‐b][1,3,4]thiadiazines

8‐Aminoquinolines with an Aminoxyalkyl Side Chain Exert in vitro Dual‐Stage Antiplasmodial Activity

Synthesis and Acaricidal Activity of Some New 1,2,4‐Triazine Derivatives

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