“…Commun., 2020, 56, 5207--5222 | 5215 the hypothesis that multimerization of a glycomimetic onto a nanometric scaffold elicits binding modes to the glycosidases that can be radically different from the binding mode of the monomer. 164 The authors capitalized on the unique stereoelectronic and chemical properties of the so-called sp 2 -iminosugar glycomimetics, 165 in which the underlining amine group of iminosugars is replaced into a trigonal planar pseudoamidetype nitrogen (N-carbonyl, N-thiocarbonyl, N-imino group), with a substantial sp 2 -hybridization nature (e.g., as in carbamate, 166 thiocarbamate, [167][168][169] urea, [170][171][172] thiourea, [173][174][175][176][177][178][179][180] isourea, [180][181][182][183][184][185][186][187] isothiourea, [187][188][189][190][191][192][193][194][195] guanidine, 196,197 sulfamide 198 or thiohydantoin 199 functionalities), to access stable O-, S-, N-and C-pseudoglycosides. [200][201][202][203][204][205]…”