Stereoselective synthesis and moulting activity of integristerone A and analogues

The metabolism of 20-hydroxyecdysone in mice: Relevance to pharmacological effects and gene switch applications of ecdysteroids

“…Initially, a 20-hydroxyecdysone derivative bearing a 1,2-unsaturation was prepared [25]. Tritiation of this compound was performed by Moravek Biochemicals Inc. (Brea, CA92821, USA) using 10% Pd/C as catalyst with tritium gas (EtOH solution, 1 h, ratio of compound/catalyst 3:1) and yielded 50 mCi [1␣,2␣-3 H]2-deoxy-20-hydroxyecdysone (spec.…”

Steroids: partial synthesis in medicinal chemistry

“…[242][243][244][245] The synthesis and moulting hormone activity of integristerone A (1b,20-dihydroxyecdysone) 55 has been reported. 246 A number of ponasterone A derivatives have been prepared and their binding to the ecdysone receptor has been evaluated. 247 Over sixty brassinosteroids are known.…”