Stereoselective synthesis and molecular modeling of chiral cyclopentanes

Molecular docking, drug-likeness and DFT study of some modified tetrahydrocurcumins as potential anticancer agents

“…They reported that five compounds of newly synthesized have IC 50 values less than 5.95 µM. In our continuous attempts to develop novel potent bioactive agents ( Abdel-Jalil et al, 2015 , El-ajaily et al, 2019 , El-Barasi et al, 2020 , Eleya et al, 2011 , Hussain et al, 2008 , Ibad et al, 2011 , Kamel et al, 2022a , Kamel et al, 2022b , Mahal, 2015a , Mahal et al, 2010 , Mahal et al, 2011 , Mahal et al, 2015b , Mahal et al, 2015c , Mahal et al, 2019 , Mahal et al, 2021 , Marzano et al, 2022 , Mohapatra et al, 2021 , Salman et al, 2011 , Salman et al, 2020 , Salman et al, 2022 , Yang et al, 2017 , Yang et al, 2018 , Zinad et al, 2020a , Zinad et al, 2020b , Zinad et al, 2020c , Zinad et al, 2020d , Zinad et al, 2021a , Zinad et al, 2021b , Zinad et al, 2022 , Zinad et al, 2023a , Zinad et al, 2023b ), we aim at this study to investigate the molecular docking and DFT calculation of potent anticancer agents of tetrahydrocurcumin.…”