Stereoselective Polar Radical Crossover for the Functionalization of Strained-Ring Systems
Dorian Didier,
Florian Trauner,
Rahma Ghazali
et al.
Abstract:Radical-polar crossover of organoborates is a poweful tool that enables the creation of two C-C bonds simultaneously. Small ring systems have become essential motifs in drug discovery and medicinal chemistry. However, step-economic methods for their selective functionalization remains scarce. Here we present a one-pot strategy that merges a simple preparation of strained organoboron species with the recently popularized polar radical crossover of borate derivatives to stereoselectively access tri-substituted a… Show more
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