Stereoselective Pharmacokinetics and Residue Depletion of Praziquantel and Its Metabolites, 4-Hydroxypraziquantel Enantiomers, in Swine
Meiyu Zhang,
Fangyu Zhang,
Jingli Qiu
et al.
Abstract:Praziquantel (PZQ) is administered as a racemic mixture during swine production to treat parasitic diseases. Despite its widespread application, the pharmacokinetics, residue depletion, bioactivity, and toxicity of PZQ enantiomers in swine remain largely unknown. In this study, a systematic investigation of the pharmacokinetics, tissue distribution, and residue depletion of PZQ, its major metabolites (trans-and cis-4-OH-PZQ), and their enantiomers was conducted in swine. The findings indicated that PZQ was abs… Show more
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