Stereoselective aldol reactions using pseudoC₂symmetric 1-benzyl-4-(trifluoromethyl)piperidine-2,6-dione

Abstract

Crossed aldol reactions of the CF-containing pseudo C symmetric cyclic imide 3 were carried out by way of the corresponding boron bisenolate to stereoselectively furnish the desired products 4 and this procedure allowed the preferential construction of the diastereomers of the compounds previously obtained from the acyclic counterpart 1.