Stereoselective Aldol Reaction of Glutarimides Using Pseudo C 2 Symmetry. -Aldol-based desymmetrization of β-substituted glutarimides (I) and (V) with the chiral oxazolidinone auxiliary is applied to construct δ-lactones, containing three consecutive chiral centers with a high level of stereocontrol. Either enantiomeric lactone can be easily synthesized by selection of the appropriate amine, (i-Pr)2NEt or Et3N. It is crucial to reduce the amount of Bu 2 BOTf and of the base using the aliphatic aldehydes (IIe,f) [cf. (IVe,f)], since the excess of the reagents lead to the enolization of the aldehydes.-(WATANABE, Y.; YAMAZAKI*, T.; KUBOTA, T.; Org. Lett. 12 (2010)