Stereology versus planimetry to estimate the volume of malignant liver lesions on MR imaging

Mazonakis, Michalis; Damilakis, John; Mantatzis, Michael; Prassopoulos, Panos; Maris, Thomas G.; Varveris, H.; Gourtsoyiannis, Nicholas

doi:10.1016/j.mri.2004.02.012

Cited by 21 publications

(16 citation statements)

References 33 publications

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“…Volumetric image acquisition with modern MR and multidetector CT systems allows precise three-dimensional measurement of tissue volumes [6]. Furthermore, post-processing of acquired images is nowadays easier for three-dimensional study of organs [15] and lesions [16]. Quantification of metastatic tumor burden in the liver can be accurately performed using volumetric acquisition provided by modern CT [17,18] and MRI.…”

Section: Discussionmentioning

confidence: 99%

Treatment response classification of liver metastatic disease evaluated on imaging. Are RECIST unidimensional measurements accurate?

et al. 2009

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The purpose of this study was to evaluate the accuracy of unidimensional measurements (response evaluation criteria in solid tumors, RECIST) compared with volumetric measurements in patients with liver metastases undergoing chemotherapy. Forty-four patients with newly diagnosed liver lesions underwent three MRI examinations at treatment initiation, during chemotherapy, and immediately post-treatment. Measurements based on RECIST guidelines and volume calculations were performed on the "target" lesions (TLs). The two methods were in agreement in 64/77 of patients and 253/301 of individual lesions classification in response categories ("good" agreement, Cohen kappa = 0.735 and 0.741, respectively). In 16.88% of the comparisons the two methods stratified patients to a different response category; 27.6% of TLs did not follow the response category of the patient in whom lesions were located. The actual volume of TLs differs from the calculated volume of a sphere with the same diameter. Our study supports the use of volumetric techniques that may overcome certain disadvantages of unidimensional measurements.

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Section: Discussionmentioning

confidence: 99%

Treatment response classification of liver metastatic disease evaluated on imaging. Are RECIST unidimensional measurements accurate?

et al. 2009

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“…The section thickness of the images is multiplied by the cut surface area of the sections and the total volume of the object of interest is estimated. The cut surface areas of the sections can be estimated using the planimetry technique that is used for estimating volume based on the Cavalieri principle (Mazonakis et al, 2004;Sahin and Ergur, 2006). …”

Section: Discussionmentioning

confidence: 99%

“…ture of interest on a section-by-section basis, it is true that the volumetric method is laborious. However, planimetric measurements are currently considered reference values in many volumetric studies (Bentley and Karwoski,1988;Dachman et al, 2001;Mazonakis et al, 2004), because they can provide accurate results whenever the user has the ability to precisely trace organ boundaries and knows the regional anatomy and morphology.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Hepatic Hydatid Cysts on the Size of Spleen

DİCLE¹,

POLAT²,

Şahin³

et al. 2011

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“…The increase in point spacing resulted in a considerable reduction in the number of counted points and, therefore, in a reduction of the time required. The mean time needed to estimate EDV with a point spacing of 10,15,20,25,30, and 35 pixels was equal to 3.7, 2.2, 1.6, 1.2, 1.1, and 0.9 min, respectively. The corresponding times for ESV estimation were 2.0, 1.1, 1.0, 0.9, 0.9, and 0.8 min, respectively.…”

Section: Optimization Of Stereological Methodsmentioning

confidence: 99%

“…However, Roberts et al [26] presented MRbased volume measurements of only one patient, whereas Graves and Dommett [27] made no attempts to optimize the volumetric method. The optimization procedure of the stereological method is a prerequisite whenever rapid and reliable volume assessments are needed [20,[28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Stereological estimation of left-ventricular volumetric and functional parameters from multidetector-row computed tomography data

et al. 2008

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This study aims to optimize the stereological method for estimating left-ventricular (LV) parameters from retrospectively electrocardiography-gated 16-row MDCT and to compare stereological estimations with those by MRI. MDCT was performed in 17 consecutive patients with known or suspected coronary disease. Stereological measurements based on point counting were optimized by determining the appropriate distance between grid points. LV parameters were evaluated by standard CT analysis using a semi-automatic segmentation method. Two independent observers evaluated the reproducibility of the stereological method. End-diastolic volume (EDV) and end-systolic volume (ESV) estimations with a coefficient of error below 5% were obtained in a mean time of 2.3 +/- 0.5 min with a point spacing of 25 and 15 pixels, respectively. The intra- and interobserver variability for estimating LV parameters was 2.6-4.4 and 4.9-8.2%, respectively. MRI estimations were highly correlated with those by standard CT analysis (R > 0.82) and stereology (R > 0.84). Stereological method significantly overestimated EDV and ESV compared to MRI (EDV: P = 0.0011; ESV: P = 0.0013), whereas for stroke volume (SV) and ejection fraction (EF), no difference was observed (P > 0.05). For standard CT analysis and MRI, significant differences were found except for SV and EF (EDV: P = 0.0008; ESV: P = 0.0004; EF: P = 0.051; SV: P = 0.064). The time-efficient optimized stereological method enables the reproducible evaluation of LV function from MDCT.

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Stereology versus planimetry to estimate the volume of malignant liver lesions on MR imaging

Cited by 21 publications

References 33 publications

Treatment response classification of liver metastatic disease evaluated on imaging. Are RECIST unidimensional measurements accurate?

Treatment response classification of liver metastatic disease evaluated on imaging. Are RECIST unidimensional measurements accurate?

The Effect of Hepatic Hydatid Cysts on the Size of Spleen

Stereological estimation of left-ventricular volumetric and functional parameters from multidetector-row computed tomography data

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