Stereologic analysis of leukocyte infiltration in oral ulcers of developing Mikulicz aphthae

Schroeder, Hubert E.; ̈ller-Glauser, W. Mu; Sallay, K

doi:10.1016/0030-4220(83)90081-6

Cited by 22 publications

(7 citation statements)

References 28 publications

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“…Patients also mentioned other food products known for their histamine‐rich or ‐releasing properties (e.g., tomatoes, peanuts, alcohol, spices, eggplants, and vinegar), although less frequently. Noteworthy, pathology studies consistently found a several‐times higher number of mast cells, the main source of histamine , in OU biopsies of patients with BD or RAS than in the mucosa of controls . Moreover, when challenged by foods, patients with RAS showed increased histamine release , and the mast‐cell stabilizer cromoglycate sodium has had some benefit for OU attacks in RAS .…”

Section: Discussionmentioning

confidence: 99%

Dietary and Nondietary Triggers of Oral Ulcer Recurrences in Behçet's Disease

Volle

Fraison

Gobert

et al. 2017

Arthritis Care & Research

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Section: Discussionmentioning

confidence: 99%

Dietary and Nondietary Triggers of Oral Ulcer Recurrences in Behçet's Disease

Volle

Fraison

Gobert

et al. 2017

Arthritis Care & Research

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“…This response may also in part derive from substance P-mediated activation of mast cells (8). since the number of mast eells is increased beneath the centers of ulcers during the ulcerative stage of recurrent aphthous ulcers (22), Mast cells are often found in membranemembrane contact with substance P containing nerves (29), However, in the present study we investigated mainly the area lateral to ulcer, in which the mast cell number decreases during the ulcerative stage (22), Calcitonin gene-related peptide is an even more potent vasodilator than substance P (1), In addition to their vasoregulatory roles, substance P and calcitonin gene-related peptide ean augment the infiammatory response in many other ways (7. 8.…”

Section: Discussionmentioning

confidence: 99%

Innervation of recurrent aphthous ulcers

Konttinen

Häyrinen-Immonen

Nordström

et al. 1994

Oral Microbiology and Immunology

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Specimens from nonkeratinized oral mucosa were obtained from diseased and clinically healthy mucosa from 7 patients with minor recurrent aphthous ulcers. The innervation of the specimens was visualized using antibodies to neuron-specific intermediate cytoskeletal neurofilament fiber, the cytoplasmic protein gene product 9.5 and a 38 kDa integral membrane protein of synaptic vesicles applied in avidin-biotin-peroxidase staining. Mapping with these 3 antibodies revealed dense and basically similar pattern of innervation in the specimens of the clinically healthy oral mucosa. In recurrent aphthous ulcers, all 3 general markers disclosed peripheral nerve fibers also in the lesions, apart from the necrotic area, among the inflammatory cells without signs of retraction from the diseased area. Synaptophysin staining suggested that these peripheral nerve fibers in the inflammatory areas still contained synaptic vesicles. Accordingly, they were shown to contain substance P and calcitonin gene-related peptide, which are known to be released upon stimulation of the nerve and can exert potent paracrine actions, possibly on the local inflammatory cells as suggested by a close spatial relationship between neuropeptide-containing nerves and inflammatory cells.

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“…Serologic studies that compared RAS patients and unaffected controls revealed diminished ratios of circulating CD4 + helper cells to CD8 + suppressor cells in the former group. 19,20 It has been proposed that in RAS some unspecified antigenic influence 21 is at the epicenter of an antibody-dependent, T cell-mediated immune response that involves a shift in local lymphocytic subpopulations that eventuates in tissue damage. [22][23][24] From the observations of several investigators it has been hypothesized that the entire process of aphthous ulceration, from initiation through progression, is instigated by the expression on oral epithelial cells of not only normally found HLA class I antigens but also HLA class II antigens.…”

Section: Immunologic Factorsmentioning

confidence: 99%