Stereoinduktion in der Metallaphotoredoxkatalyse

Abstract

Gary Molander schloss sein Studium der Chemie an der Iowa State University unter der Anleitung von Professor Richard C. Larock ab. Auf seine Promotion an der Purdue University in der Gruppe von Professor Herbert C. Brown folgte ein Forschungsaufenthalt bei ProfessorB arry M. Trost an der University of Wisconsin, Madison. Er begann seine akademische Laufbahn an der University of Colorado, Boulderu nd wechselte 1999 an die University of Pennsylvania, wo er aktuell als Hirschmann-Makineni-Professor fürC hemie tätig ist. Schema 1. Enantioselektive Kreuzkupplung mit Benzyltrifluoroboraten durch duale Photoredox/Ni-Katalyse. Schema 2. Enantioselektive Kreuzkupplung mit A) a-Trifluormethyltrifluoroboratenu nd B) a-Alkoxymethyltrifluoroboratendurch duale Photoredox/Ni-Katalyse.

Photoredox‐Mediated Deoxygenative Radical Additions of Aromatic Acids to Vinyl Boronic Esters and gem‐Diborylalkenes**

“…Driven by environmental and economic requirements, the modern photoredox‐mediated chemical synthesis of organic molecules has emerged as a truly powerful protocol to develop new, [1] chemoselective, and efficient methods toward carbon‐carbon and carbon–heteroatom bond construction [2] . In this regard, the advancement of the photoredox‐mediated chemistry of carbocylic acids ( 1 ) has had an enormous impact on enabling new chemical reactions and has extended the scope of accessible molecular scaffolds (Figure 1A and B) [2a,g–i,3] . These reactions are particularly attractive because, owing to the wide availability of carboxylic acids in natural products, for example, bioactive compounds [4] and drug molecules [3f,5] .…”