Stereofacial Control in Asymmetric Cyanosilylation of Aldehydes Catalyzed by Novel S‐Proline‐Derived Titanium Complexes.

Abstract

Nitriles Q 0520 Stereofacial Control in Asymmetric Cyanosilylation of Aldehydes Catalyzed by Novel S-Proline-Derived Titanium Complexes. -Titanium catalysts derived from C2-symmetric ligands (II) give (R)-configurated cyanosilylated products from the reaction of aromatic aldehydes with TmsCN. Catalysts derived from amino alcohol (Ia) or aminophosphine (Ib) afford the (S)-cyanohydrin. -(KIM, Y. B.; KIM, M. K.; KANG, S. H.; KIM*, Y. H.; Synlett