Stereodivergent Total Synthesis of Ethyl Plakortide Z
Nicolas Jamey,
Laurent Ferrié
Abstract:Plakortides make up a subclass of marine endoperoxides with diverse biological activities. Their structural particularity is derived from the C 4 and C 6 positions of the endoperoxide, which are substituted by ethyl groups. The ethyl plakortide Z has the simplest side chain among its congeners and is an excellent target for testing a universal strategy for the synthesis of this subfamily. Accordingly, we have synthesized for the first time a six-membered plakortide using asymmetric Enders alkylation, regiosele… Show more
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