Stereochemistry of Lignans in Phaleria macrocarpa (Scheff.) Boerl.

Abstract

Phaleria macrocarpa (Scheff.) Boerl., a member of the Thymelaeaceae, is traditionally used in Indonesia as medicinal plant against cancer. In this context, we isolated the lignans pinoresinol, lariciresinol and matairesinol from different parts of this plant. The enantiomeric composition of these lignans was determined by chiral column analysis. Pinoresinol and lariciresinol were mixtures of both enantiomers with (79 ± 4)% and (55 ± 6)% enantiomeric excess for the (−)-enantiomers, respectively, whereas matairesinol was found as pure (+)-enantiomer.

Phytochemistry and medicinal properties of Phaleria macrocarpa (Scheff.) Boerl. extracts

“…[6] Lignans isolated from different parts of P. macrocarpa , when subjected to chiral column analysis, have been found to include pinoresinol (79 ± 4% [−] -enantiomer excess), lariciresinol (55 ± 6% [−] -enantiomer excess) and matairesinol (pure [+] -enantiomers). [7] The bark and fruits are rich in saponins, alkaloids, polyphenolics, phenols, flavanoids, lignans and tannins. [8910] Isolated constituents of fruit include Icariside C3, magniferin, and gallic acid.…”

Antipyretic Effects of (phaleria macrocarpa (scheff) boerl.) Infusa In Mice Galur Wistar As Animal Model

“…Pit is round, white and poisonous [3] and fruit is of eclipse shape with a diameter of 3 cm. Fruits are green when un-ripened and become red on ripening [4].…”

Phytochemical and toxicity evaluation of Phaleria macrocarpa (Scheff.) Boerl by MCF-7 cell line and brine shrimp lethality bioassay

“…The seeds of P. macrocarpa are very toxic and have unpleasant taste due to the presence of 29-norcucurbitacin, desacetylfevicordin A and other 29-norcucurbitacin derivatives, fevicordin A, fevicordin A glucoside and fevicordin D glucoside [13]. Seed of P. macrocarpa also contained flavonoid known as viz.…”