Stereochemical Heterogeneity Analysis of Polylactides by Multidimensional Liquid Chromatography
Paul S. Eselem Bungu,
Karola Luetzow,
Olaf Lettau
et al.
Abstract:A new and robust high-performance liquid chromatography (HPLC) method that separates poly(lactic acid) (PLA) according to its stereochemical composition is presented. Using this method, poly(L-lactide) incorporating trace amounts of meso-lactide resulting from the racemization is separated from the pristine polymer. To prove this aspect in more detail, a representative poly(L-lactic acid) standard, assumed to be highly homogeneous, was separated using this method. The result showed that this was not the case a… Show more
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