Stereochemical aspects of drug action and disposition

Chiral separation by chromatographic and electromigration techniques. A Review

“…The pharmacologically inactive enantiomer (distomer) can show unwanted side effects; in some cases antagonistic and even toxic effects are observed. The enantiomers can differ in absorption, distribution, protein binding and affinity to the receptor [2]. Furthermore, the metabolic pathways can differ.…”

Thin-layer chromatographic enantioseparation of ofloxacin and zopiclone using hydroxy-propyl-beta-cyclodextrin as chiral selector and thermodynamic studies of complexation

“…Nevertheless, only about 25% of drugs are administered as pure enantiomers. The enantiomers can differ in absorption, distribution, protein binding, and affinity to the receptor [23]. Furthermore, the metabolic pathways can differ.…”

The Chain of Chirality Transfer as Determinant of Brain Functional Laterality. Breaking the Chirality Silence: Search for New Generation of Biomarkers; Relevance to Neurodegenerative Diseases, Cognitive Psychology, and Nutrition Science

“…ondary, tertiary, and higher-ordered structures assumed to be responsible for their prominent role in the chirality transformation events. The members of protein family known for chirality related functions include enzymes III [25], cytoskeleton molecular complex [26], amylogenic proteins [27,28], trans-membrane proteins -ligand complex [29], drugs IV [30,31], and antibiotics V [32,33]. For the purpose of our review we will restrict our attention mostly to the proteins and phospholipids.…”