Stereo‐Controlled Synthesis of Vicinal Tertiary Carbinols: Application in the Synthesis of a Diol Substructure of Zaragozic Acid, Pactamycin and Ryanodol
Byungjoo Kim,
Ravi Kumar Puthukanoori,
Bhikshapathi Martha
et al.
Abstract:A novel and flexible approach for the stereo‐controlled synthesis of vicinal tertiary carbinols is reported. The developed strategy featured a highly diastereoselective singlet‐oxygen (O21) [4+2] cycloaddition of rationally designed cyclohexadienones (derived from oxidative dearomatization of the corresponding carboxylic‐acid appended phenol precursors), followed by programmed “O−O” and “C−C” bond cleavage. In doing so, a highly functionalized and versatile intermediate was identified and prepared in synthetic… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.