Stepwise regression analysis to study male and female factors impacting on pregnancy rate in an intrauterine insemination programme

Gauci, M. Montanaro; Kruger, Thinus F.; Coetzee, Kevin; Smith, Karen L.; Merwe, J. P. van der; Lombard, Carl

doi:10.1046/j.1439-0272.2001.00428.x

Cited by 63 publications

(18 citation statements)

References 22 publications

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“…There are several studies that have concluded that IUI is not an effective treatment in male factor infertility [12,13]. We used the standard definition of male factor infertility using the WHO criteria for normal semen parameters in this study.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Processed Total Motile Sperm Counts and Twenty Four Hour Sperm Survival on the Efficacy of Intrauterine Insemination in Male Infertility

Branigan¹,

Estes²,

Walker³

2017

Andrology

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Objective: To compare the effectiveness of IUI, based on Pre-treatment Semen analysis results, in treating male factor infertility. Design:A retrospective cohort design of 1,768 infertile couples undergoing 5,219 IUI cycles, who had pretreatment advanced semen analysis were evaluated. An advanced semen analysis consists of a basic semen analysis and processed total motile sperm counts through a density gradient sperm prep and recording 24 hours sperm survival of these sperm culture media in an incubator. Logistic regression analysis was used to assess the significance of prognostic factors in sperm parameters to predict the pregnancy rates with IUI. Results:No basic semen analysis parameter accurately predicted IUI success. Clinical pregnancy rate for first cycle of IUI was 15.6% when >10 × 10 6 processed total motile sperm was available and 13.7% in all cycles. This group contained 1264/1768 (71.5%) of couples in the study. The pregnancy rate in the first cycle was 18.2% if their 24 hour survival was >70% and 15.9% in all cycles and 1008/1264 (57%) of couples were in this group. No pregnancy was achieved for processed total motile sperm counts <5 × 10 6 (168/1768) or 9.5% of couples and 3.6% for those with 24 hour survivals <30% in first cycle and 2.0% for all cycles for 601/1768 (34%) of the couples. Strong positive correlations between processed total motile sperm counts and PR (r=0.83; p<0.001) and between 24 hours survival and PR (r=0.79; p<0.001) were seen by linear regression analysis. High correlations were also noted between processed total motile sperm counts (r=0.71; p<0.001) and 24 hours survivals (r=0.76; p<001) in the advanced semen analysis and those in the IUI samples. Conclusion:Both processed total motile sperm counts and 24 hour survival are useful predictors of whether a couple should be treated with levels below threshold levels have a very poor prognosis with IUIs.

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Section: Discussionmentioning

confidence: 99%

The Effect of Processed Total Motile Sperm Counts and Twenty Four Hour Sperm Survival on the Efficacy of Intrauterine Insemination in Male Infertility

Branigan¹,

Estes²,

Walker³

2017

Andrology

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“…2001). When normal sperm morphology exceeds 14%, the chance of pregnancy after IUI is 1.8 times higher than when it is lower than 14% (Montanaro Gauci et al. 2001).…”

Section: Semen Quality In Animals and Humansmentioning

confidence: 95%

“…To achieve acceptable pregnancy rates after IUI, at least 5% of the spermatozoa have to be morphologically normal (Ombelet et al. 1997; Montanaro Gauci et al. 2001; Van Waart et al.…”

Section: Semen Quality In Animals and Humansmentioning

confidence: 99%

Intra‐uterine Insemination in Farm Animals and Humans

Verberckmoes

Soom

Kruif

2004

Reprod Domestic Animals

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Artificial insemination (AI) is the oldest and currently most common technique in the assisted reproduction of animals and humans. The introduction of AI in farm animals was forced by sanitary reasons and the first large-scale applications with a commercial goal were performed in cattle in the late 1930s of last century. After the Second World War, cryopreservation of semen facilitated distribution and AI was mainly performed for economic reasons, especially in dairy cattle industry. In humans however, AI was initially performed in cases of physiological and psychological sexual dysfunction, but later on also in cases of infertility caused by immunological problems. Currently, the most common indications for intra-uterine insemination (IUI) in humans are unexplained infertility and male subfertility. In these cases, IUI is considered as the treatment of the first choice, before more invasive techniques such as in vitro fertilization (IVF) and intracytoplasmatic sperm injection (ICSI) are used. In contrast with humans, the quantity and quality of semen produced by farm animals is much higher and permits dilution and production of several insemination doses per ejaculate. However, with the introduction of sex-sorted semen in farm animals, the same problem of low-quality semen as in humans has arisen. In cattle, pigs and horses, conventional insemination with low numbers of sex-sorted spermatozoa results in a significant decrease in fertility. To improve the fertility rates with this semen, new insemination techniques have been developed in order to deposit spermatozoa closer to the site of fertilization. In sows and mares the advantage of utero-tubal junction (UTJ) insemination has already been proven; however, in cattle it is still under investigation. In this review, the differences and similarities in the application of AI between animals and humans are discussed and as AI in farm animals is most successful in cattle, the situation in this species is elaborated the most.

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“…The link between sperm motility and IUI success was addressed in several studies. Briefly, in these studies, total motile sperm of 30–50% before sperm preparation was found to be associated with positive IUI outcomes [54, 56, 57]. …”

Section: Semen Parameters and The Use Of Iuimentioning

confidence: 99%

The Potential Use of Intrauterine Insemination as a Basic Option for Infertility: A Review for Technology-Limited Medical Settings

Abdelkader

Yeh

2009

Obstetrics and Gynecology International

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Objective. There is an asymmetric allocation of technology and other resources for infertility services. Intrauterine insemination (IUI) is a process of placing washed spermatozoa transcervically into the uterine cavity for treatment of infertility. This is a review of literature for the potential use of IUI as a basic infertility treatment in technology-limited settings. Study design. Review of articles on treatment of infertility using IUI. Results. Aspects regarding the use of IUI are reviewed, including ovarian stimulation, semen parameters associated with good outcomes, methods of sperm preparation, timing of IUI, and number of inseminations. Implications of the finding in light of the needs of low-technology medical settings are summarized. Conclusion. The reviewed evidence suggests that IUI is less expensive, less invasive, and comparably effective for selected patients as a first-line treatment for couples with unexplained or male factor infertility. Those couples may be offered three to six IUI cycles in technology-limited settings.

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Stepwise regression analysis to study male and female factors impacting on pregnancy rate in an intrauterine insemination programme

Cited by 63 publications

References 22 publications

The Effect of Processed Total Motile Sperm Counts and Twenty Four Hour Sperm Survival on the Efficacy of Intrauterine Insemination in Male Infertility

The Effect of Processed Total Motile Sperm Counts and Twenty Four Hour Sperm Survival on the Efficacy of Intrauterine Insemination in Male Infertility

Intra‐uterine Insemination in Farm Animals and Humans

The Potential Use of Intrauterine Insemination as a Basic Option for Infertility: A Review for Technology-Limited Medical Settings

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