Stepwise pH-responsive nanoparticles containing charge-reversible pullulan-based shells and poly(β-amino ester)/poly(lactic-co-glycolic acid) cores as carriers of anticancer drugs for combination therapy on hepatocellular carcinoma

Zhang, Cong; An, Tong; Wang, Dan; Wan, Guoyun; Zhang, Mingming; Wang, Hemei; Zhang, Sipei; Li, Rongshan; Yang, Xiaoying; Wang, Yinsong

doi:10.1016/j.jconrel.2016.02.030

Cited by 114 publications

(78 citation statements)

References 34 publications

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“…By contrast, PDFI nanoparticles evidently increased the tumor accumulation and slightly decreased the liver distribution of IR780, further confirming their tumor-targeting and accumulating ability. According to our previous reports, 19,20 we believed that the EPR effect due to nanoscaled particle size and specific affinity of pullulan for ASGPR both played major roles in HCC-targeted delivery of PDFI nanoparticles in vivo.…”

Section: In Vivo Distribution Of Pdfi Nanoparticlesmentioning

confidence: 88%

“…Obvious histopathological changes such as vascular congestion, tissue swelling and cell debris were visible in the liver of mice treated with free PTX, which was consistent with previously reported observation that PTX could induce the liver injury due to its distinct toxicity. 20 However, no obvious abnormality was detected in the liver of mice treated with PDFP nanoparticles, demonstrating that the hepatotoxicity of PTX was remarkably reduced by HCC-targeted delivery of PDFP nanoparticles. In view of the strong antiangiogensis activity of PTX, 38 we further evaluated the intratumoral vascularization after various treatments using the immunohistochemical staining of CD31.…”

mentioning

confidence: 94%

“…Pullulan is a natural ligand for asialoglycoprotein receptor (ASGPR) that is often overexpressed by HCC cells, 18 and we have used it for HCC-targeted delivery of anticancer drugs or genes in our previous reports. 19,20 Hereby, IR780-and PTX-loaded PDF nanoparticles, respectively, named as PDFI and PDFP nanoparticles, were prepared for HCC-targeted delivery and/or accumulation of these 2 drugs. Our therapeutic strategy for HCC is illustrated in Scheme 1.…”

Section: Introductionmentioning

confidence: 99%

“…This toxicity-attenuation effect was also observed in other pullulan-based nanoparticle systems. 20 The body weights of mice treated with PDFI nanoparticles/laser irradiation significantly decreased during the first 6 days, but afterwards increased slightly. It indicated that phototherapy induced by PDFI nanoparticles also had a little in vivo toxicity.…”

mentioning

confidence: 97%

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Pullulan-coated phospholipid and Pluronic F68 complex nanoparticles for carrying IR780 and paclitaxel to treat hepatocellular carcinoma by combining photothermal therapy/photodynamic therapy and chemotherapy

Wang

Zhang

et al. 2017

IJN

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IR780, a near-infrared dye, can also be used as a photosensitizer both for photothermal therapy (PTT) and photodynamic therapy (PDT). In this study, we designed a simple but effective nanoparticle system for carrying IR780 and paclitaxel, thus hoping to combine PTT/PDT and chemotherapy to treat hepatocellular carcinoma (HCC). This nanosystem, named PDF nanoparticles, consisted of phospholipid/Pluronic F68 complex nanocores and pullulan shells. IR780 and paclitaxel were loaded separately into PDF nanoparticles to form PDFI and PDFP nanoparticles, which had regular sphere shapes and relatively small sizes. Upon near-infrared laser irradiation at 808 nm, PDFI nanoparticles showed strong PTT/PDT efficacy both in vitro and in vivo. In MHCC-97H cells, the combined treatment of PDFI nanoparticles/laser irradiation and PDFP nanoparticles exhibited significant synergistic effects on inhibiting cell proliferation and inducing cell apoptosis and cell cycle arrest at G2/M phase. In MHCC-97H tumor-bearing mice, PDFI nanoparticles exhibited excellent HCC-targeting and accumulating capability after intravenous injection. Furthermore, the combined treatment of PDFI nanoparticles/laser irradiation and PDFP nanoparticles also effectively inhibited the tumor growth and the tumor angiogenesis in MHCC-97H tumor-bearing mice. In summary, we put forward a therapeutic strategy for HCC treatment by combining PTT/PDT and chemotherapy.

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Section: In Vivo Distribution Of Pdfi Nanoparticlesmentioning

confidence: 88%

mentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 97%

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Pullulan-coated phospholipid and Pluronic F68 complex nanoparticles for carrying IR780 and paclitaxel to treat hepatocellular carcinoma by combining photothermal therapy/photodynamic therapy and chemotherapy

Wang

Zhang

et al. 2017

IJN

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“…92 Mediating through interaction between polysaccharide backbone of pullulan and ASGPR, the pullulan-coated drug carrier significantly inhibited hepatoma cell proliferation and migration, as well as tumor growth and angiogenesis. 93 …”

Section: Retinoic Acid Biotinmentioning

confidence: 99%

Ligand-based targeted therapy: a novel strategy for hepatocellular carcinoma

Li¹,

Zhang²,

Wang³

et al. 2016

IJN

117

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Poly(β‐Amino Esters): Synthesis, Formulations, and Their Biomedical Applications

Liu

Keskin

et al. 2018

Adv Healthcare Materials

134

146

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drugs, antimicrobials, proteins delivery, and tissue repair. PBAEs are synthesized via a one-pot Michael addition of amines to acrylates (Scheme 1) without the production of any byproducts. The hydrolytically degradable ester bonds provide PBAEs with excellent biodegradability, thus reducing the cytotoxicity caused by necrosis and apoptosis. [5] The tertiary amine groups can electrostatically interact with negatively charged gene [6] or therapeutics [7] to form nanocomposites. Besides, the amino groups undergo phase transition upon the charge of surrounding pH, possessing pH-responsive and charge reversible properties, [8,9] and those properties make the PBAEs promising candidates for controlled and programmable release. [10] The key factor of PBAEs is their potential for structural diversity due to the combination of different monomers. [4] In addition, PBAEs are compatible with a wide range of polymers, for instance, poly(ethylene glycol) (PEG), [11] poly (lactic acid) (PLA), [12] and poly(ε-caprolactone) (PCL) [13] to form block copolymers. Taken together, these cases demonstrated the versatility of the PBAEs in the modification of their physical, chemical, and mechanical properties. In this review, we emphasize all types of PBAE-based formulations, namely, nanocomposites, micelles, hydrogels, and films for therapeutics delivery and tissue repair applications. MonomersDiverse acrylates (A) were employed in PBAE synthesis, as shown and classified in Figure 1. The functional groups like alkyl, aryl, and ester groups (A1-A14) are hydrophobic, which Poly(β-amino ester) (abbreviated as PBAE or PAE) refers to a polymer synthesized from an acrylate and an amine by Michael addition and has properties inherent to tertiary amines and esters, such as pH responsiveness and biodegradability. The versatility of building blocks provides a library of polymers with miscellaneous physicochemical and mechanical properties. When used alone or together with other materials, PBAEs can be fabricated into different formulations in order to fulfill various requirements in drug delivery (for instance, gene, anticancer drugs, and antimicrobials delivery) and natural complex mimicry (nanochaperones). This progress report discusses the recent developments in design, synthesis, formulations, and applications of PBAEs in biomedical fields and provides a perspective view for the future of the PBAEs.

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Stepwise pH-responsive nanoparticles containing charge-reversible pullulan-based shells and poly(β-amino ester)/poly(lactic-co-glycolic acid) cores as carriers of anticancer drugs for combination therapy on hepatocellular carcinoma

Cited by 114 publications

References 34 publications

Pullulan-coated phospholipid and Pluronic F68 complex nanoparticles for carrying IR780 and paclitaxel to treat hepatocellular carcinoma by combining photothermal therapy/photodynamic therapy and chemotherapy

Pullulan-coated phospholipid and Pluronic F68 complex nanoparticles for carrying IR780 and paclitaxel to treat hepatocellular carcinoma by combining photothermal therapy/photodynamic therapy and chemotherapy

Ligand-based targeted therapy: a novel strategy for hepatocellular carcinoma

Poly(β‐Amino Esters): Synthesis, Formulations, and Their Biomedical Applications

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