2024
DOI: 10.1101/2024.06.28.601028
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Stepwise developmental mimicry generates proximal-biased kidney organoids

Jack Schnell,
Zhen Miao,
MaryAnne Achieng
et al.

Abstract: The kidney maintains body fluid homeostasis by reabsorbing essential compounds and excreting waste. Proximal tubule cells, crucial for renal reabsorption of a range of sugars, ions, and amino acids, are highly susceptible to damage, leading to pathologies necessitating dialysis and kidney transplants. While human pluripotent stem cell-derived kidney organoids are used for modeling renal development, disease, and injury, the formation of proximal nephron cells in these 3D structures is incomplete. Here, we desc… Show more

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