Stepwise Assembly of Surface Imprint Sites on MCM-41 for Selective Metal Ion Separations

Burleigh, Mark C.; Dai, Sheng; Hagaman, Edward W.; Barnes, Craig E.; Cook, Tabitha M.

doi:10.1021/bk-2001-0778.ch010

Cited by 22 publications

(7 citation statements)

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“…29 Moreover, MSNPs present a site-selective controlled-release pattern by surface functionalization via any of the following three methods: cocondensation (one-pot synthesis), grafting (postsynthesis modification), and imprint coating. [30][31][32] For example, MSNPs functionalized with chitosan have a pH-triggered release characteristic, due to the swelling effect of chitosan in acidic environments. 33 This nanomedicine was used to deliver an oral sustained drug, carvedilol, with loading content and efficiency reaching 32.49%±1.57% and 96.25%±3.12%, respectively.…”

Section: Mesoporous Silica-based Materials As Carriersmentioning

confidence: 99%

High drug-loading nanomedicines: progress, current status, and prospects

Shen

Liu

et al. 2017

IJN

413

268

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Drug molecules transformed into nanoparticles or endowed with nanostructures with or without the aid of carrier materials are referred to as “nanomedicines” and can overcome some inherent drawbacks of free drugs, such as poor water solubility, high drug dosage, and short drug half-life in vivo. However, most of the existing nanomedicines possess the drawback of low drug-loading (generally less than 10%) associated with more carrier materials. For intravenous administration, the extensive use of carrier materials might cause systemic toxicity and impose an extra burden of degradation, metabolism, and excretion of the materials for patients. Therefore, on the premise of guaranteeing therapeutic effect and function, reducing or avoiding the use of carrier materials is a promising alternative approach to solve these problems. Recently, high drug-loading nanomedicines, which have a drug-loading content higher than 10%, are attracting increasing interest. According to the fabrication strategies of nanomedicines, high drug-loading nanomedicines are divided into four main classes: nanomedicines with inert porous material as carrier, nanomedicines with drug as part of carrier, carrier-free nanomedicines, and nanomedicines following niche and complex strategies. To date, most of the existing high drug-loading nanomedicines belong to the first class, and few research studies have focused on other classes. In this review, we investigate the research status of high drug-loading nanomedicines and discuss the features of their fabrication strategies and optimum proposal in detail. We also point out deficiencies and developing direction of high drug-loading nanomedicines. We envision that high drug-loading nanomedicines will occupy an important position in the field of drug-delivery systems, and hope that novel perspectives will be proposed for the development of high drug-loading nanomedicines.

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Section: Mesoporous Silica-based Materials As Carriersmentioning

confidence: 99%

High drug-loading nanomedicines: progress, current status, and prospects

Shen

Liu

et al. 2017

IJN

413

268

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“…As a result, the materials with a kinetically promising and highly sorbent efficiency are achieved. MCM-41 carry a huge number of silanols on their surface, which are useful for grafting of organofunctional ligands having a strong affinity with metal ions (Burleigh, Dai, Hagaman, Barnes, & Xue, 2000). The imprint coating approach does not involve the use of free ligands; rather it is related to the surface coverage of MPSNPs having ligands.…”

Section: Imprint Coating Approachmentioning

confidence: 99%

“…The removal of metal ions does not affect the linkage of ligands with the cavity wall. The linkage persists in a definite number and arrangement until the ligands identify or selectively target a molecules (Burleigh et al, 2000). In addition, the stereochemistry of surface-bound ligands is not affected by the coating method (Bruhwiler, 2010).…”

Section: Imprint Coating Approachmentioning

confidence: 99%

Targeted and stimuli–responsive mesoporous silica nanoparticles for drug delivery and theranostic use

Aquib

Farooq

Banerjee

et al. 2019

J Biomedical Materials Res

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For cancer therapy, the usefulness of mesoporous silica nanoparticles (MPSNPs) has been widely discussed, likely due to its inorganic nature and excellent structural features. The MPSNPs‐based chemotherapeutics have been promisingly delivered to their target sites that help to minimize side effects and improve therapeutic effectiveness. A wide array of studies have been conducted to functionalize drug‐loaded MPSNPs using targeting ligands and stimuli‐sensitive substances. In addition, anticancer drugs have been precisely delivered to their target sites using MPSNPs, which respond to multi‐stimuli. Furthermore, MPSNPs have been extensively tested for their safety and compatibility. The toxicity level of MPSNPs is substantially lower as compared to that of colloidal silica; however, in oxidative stress, they exhibit cytotoxic features. The biocompatibility of MPSNPs can be improved by modifying their surfaces. This article describes the production procedures, functionalization, and applications of biocompatible MPSNPs in drug delivery.

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“…163,164 The cocondensation (precipitation) method utilizes various (organo)siloxane precursors in a one-pot (hydrothermal) sol-gel process. 81,[165][166][167][168][169][170][171][172][173][174] This method is particularly viable for the incorporation of organic moieties into the pore walls as shown in the case of bifunctional periodic mesoporous organosilicas.…”

Section: Surface Functionalizationmentioning

confidence: 99%

“…By employing just enough water in the process to form a monolayer on the pore surface, more homogeneous coverage of organoalkoxysilanes can be obtained, leading to a higher concentration of functional groups in the final product. 187 Recently, Burleigh and coworkers 164 reported a new imprint coating method. They coated the mesoporous surface of MCM-41 with ligands that were already bound to metal ions, not just to the free ligands.…”

Section: Surface Functionalizationmentioning

confidence: 99%