Steps in the investigation and management of low semen volume in the infertile man

Roberts, Matthew; Jarvi, Keith

doi:10.5489/cuaj.1180

Cited by 44 publications

(28 citation statements)

References 46 publications

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“…In addition, age-related reduction in sexual intercourse and ejaculation frequency may lead to accessory gland pathologies, i.e. prostatitis and bladder outlet obstruction, reduced fluid secretion from the prostate and seminal vesicles, and therefore to decreased semen volume (25). Similar statistically significant associations between BOO and semen parameters have been revealed in multiple regression analysis.…”

Section: Discussionsupporting

confidence: 68%

Decline of seminal parameters in middle-aged males is associated with lower urinary tract symptoms, prostate enlargement and bladder outlet obstruction

Ausmees¹,

Korrovits²,

Timberg³

et al. 2013

Int. braz j urol.

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Purpose: We aimed to compare the associations between semen quality, associated reproductive indicators and the main prostate-related parameters in middle-aged men. Materials and Methods: This is a prospective study on 422 middle-aged men who underwent the screening for prostate health. Their reproductive function, semen quality and prostate-related pathologies were investigated. Results: Significant associations between semen quality and prostate-related parameters could be seen. Total sperm count and sperm density decreased along with the increase of the I-PSS score and total prostate volume. Also, the related lower urinary tract characteristics showed a negative correlation with main semen parameters for all investigated subjects. no significant differences in age, testicular size, and hormonal parameters were found between the subjects with or without lower urinary tract symptoms and prostate enlargement. Conclusions: Our study suggests that altered seminal parameters in middle-aged men are associated with LUTS, prostate enlargement and/or bladder outlet obstruction. Although the assessments of prostate and lower urinary tract symptoms may not replace the semen parameters evaluating the male reproductive status, there is a need for further and more detailed investigations about the pathways behind these associations as well as possible related conditions.

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Section: Discussionsupporting

confidence: 68%

Decline of seminal parameters in middle-aged males is associated with lower urinary tract symptoms, prostate enlargement and bladder outlet obstruction

Ausmees¹,

Korrovits²,

Timberg³

et al. 2013

Int. braz j urol.

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“…A normal volume of semen is needed to promote spermatozoon entry into cervix, buffer the luminal secretions in reproductive tract and maintain sperm activity (Menkveld, ). Inadequate semen volume is one of the causes of male infertility (Roberts & Jarvi, ). The androgen‐dependent epithelia of prostate and seminal vesicles have a key role in fluid transport and can produce a large amount of water and protein‐rich secretions, which consist of most of the ejaculate volume.…”

mentioning

confidence: 99%

Effect of androgen deprivation on the expression of aquaporins in rat prostate and seminal vesicles

et al. 2015

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The aim of this study was to investigate the level of secretions of prostate and seminal vesicles and its association with the expression of AQP0, 1, 4, 5, 6 and 8 in castrated rats. Eight-week-old male Sprague-Dawley (SD) rats (n = 18) were randomly divided into control group, castrated rats group and castrated followed testosterone replacement group. Four weeks after surgery, the secretions and expression of AQP0, 1, 4, 5, 6 and 8 of prostate and seminal vesicles were determined. Serum testosterone was significantly lower in castrated groups than in control and testosterone replacement groups (P < 0.05). The level of prostate and seminal vesicle secretions and the expressions of AQP0, 1, 4, 5, 6 and 8 in prostate and seminal vesicles were significantly lower in castrated group than in control and castrated followed testosterone replacement groups (P < 0.05). The decreased prostatic and seminal vesicle secretions in castrated rats may be related to the decrease in AQP0, 1, 4, 5, 6 and 8 in prostatic tissue and seminal vesicles.

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“…Moreover, the most common reason for RE in patients in infertility clinics is a history of retroperitoneal lymph node dissection (RPLND) for the treatment of testicular cancer. Other major reasons are peripheral neuropathy from diabetes mellitus, surgery (surgery of the bladder neck, transurethral resection of prostate gland), trauma, and idiopathic causes [19,20]. The most useful assessment of RE is evaluation of post-orgasm or postcoital urine samples.…”

Section: Delayed Ejaculationmentioning

confidence: 99%

“…Semen analysis is the most important examination for the diagnosis of male infertility. An adequate volume of ejaculate is required to carry the male gametes into the female reproductive tract, so ejaculate volume is an essential component of semen analyses [20]. If EjD affects the semen quality of infertile men, then their ejaculate volumes usually decrease or diminish; hence, ejaculate volume should be routinely investigated to detect and treat the low semen volume of EjD-related infertility.…”

Section: Ejd and Infertilitymentioning

confidence: 99%

“…Different medical treatments based on increasing the sympathetic tone or decreasing parasympathetic activity have been applied as the first choice for patients with RE and AE. Among various a-adrenergic agonists or anticholinergic and antihistaminic drugs, the two agents most commonly used are imipramine and pseudoephedrine [20,32]. For a long time, imipramine has been used for the reversal of ejaculatory disorders due to postoperative disruption of sympathetic innervations [33].…”

Section: Medicationsmentioning

confidence: 99%

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Ejaculatory dysfunction as a cause of infertility

Kondoh¹

2011

Reprod Medicine & Biology

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Ejaculatory dysfunction (EjD), the most prevalent male sexual disorder, is clearly different from erectile dysfunction (ED). EjD is divided into 4 categories: premature ejaculation, delayed ejaculation, retrograde ejaculation and anejaculation. EjD-related infertility is one of the most serious problems in young patients. If sexual intercourse is achieved successfully without any ejaculate sexual partners/wives will not be able to conceive. Therefore, establishment of management of EjD as well as ED is increasingly crucial for couples wishing for a baby. The therapeutic approach of EjD-related infertility is based upon two scenarios: (1) if EjD alone is the reason for having no children, adequate treatment for EjD alone is required, or (2) if EjD is not the only reason and is combined with a worsening of semen quality, total management for male infertility (including EjD treatment) is needed. In this article, the background of EjD-related infertility is presented briefly, followed by a review of treatment modalities.

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Steps in the investigation and management of low semen volume in the infertile man

Cited by 44 publications

References 46 publications

Decline of seminal parameters in middle-aged males is associated with lower urinary tract symptoms, prostate enlargement and bladder outlet obstruction

Decline of seminal parameters in middle-aged males is associated with lower urinary tract symptoms, prostate enlargement and bladder outlet obstruction

Effect of androgen deprivation on the expression of aquaporins in rat prostate and seminal vesicles

Ejaculatory dysfunction as a cause of infertility

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