Stephalagine, an alkaloid with pancreatic lipase inhibitory activity isolated from the fruit peel of Annona crassiflora Mart.

Pereira, Mariana Nunes; Justino, Allisson Benatti; Martins, Mário Machado; Peixoto, Leonardo Gomes; Vilela, Danielle Diniz; Santos, Paula de Souza; Teixeira, Thaíse Lara; Silva, Cláudio Vieira da; Goulart, Luíz Ricardo; Pivatto, Marcos

doi:10.1016/j.indcrop.2016.12.038

Cited by 41 publications

(38 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Other bis-indol alkaloids with lipase inhibitory activity from the same plant were conophyllinine, conophyllidine and taberhanine (Sridhar et al, 2017). The isoquinoline alkaloid stephalagine had more than 10 times higher lipase inhibitory activity that the ethanolic extract of Annona crassiflora Mart (Pereira et al, 2017).…”

Section: In Vitro Studiesmentioning

confidence: 92%

Causes and solutions to “globesity”: The new fa(s)t alarming global epidemic

Vasileva

Marchev

Georgiev

2018

Food and Chemical Toxicology

View full text Add to dashboard Cite

Diverse groups of factors are leading to increased weight gain and obesity, such as certain genetic phenotypes, neuroendocrine disturbances, the administration of some drugs, behavioral, social and environmental factors. The progressively escalating rates of overweight and obesity worldwide have led to an introduction of a new term "globesity". Excessive accumulation of body fat and especially of visceral adipose tissue is the main predisposing factor for the development of metabolic syndrome and other obesity related co-morbidities. At the present moment only few pharmacotherapeuticals are used for long-term treatment of obesity acting on narrow target spectra, e.g. pancreatic and gastric lipase inhibition, acting as adrenomimetics or activating the satiety centers in hypothalamus. Plant-based medications that accelerate weight loss, proved to be safe, effective and widely available, would be a preferable alternative for anti-obesity treatments. As plant extracts are multi-component systems they could also act by more than one mechanism, including decreased lipid absorption, decreased energy intake, increased energy expenditure, decreased pre-adipocyte differentiation and proliferation, decreased lipogenesis and increased lipolysis. The current review gives a summary of the risk factors for obesity development and its characteristics consequences. Current treatment options, combining lifestyle changes and conventional treatment with commercial anti-obesity drugs have been described as well. Special emphasis on in vitro, in vivo and human studies, of potential medicinal plant extracts and phytochemicals, such as polyphenols, terpenoids, alkaloids, saponins, able to modulate the molecular pathways and gene/protein expressions related to obesity, have been highlighted.

show abstract

Section: In Vitro Studiesmentioning

confidence: 92%

Causes and solutions to “globesity”: The new fa(s)t alarming global epidemic

Vasileva

Marchev

Georgiev

2018

Food and Chemical Toxicology

View full text Add to dashboard Cite

show abstract

“…Previous studies have demonstrated various biological activities of extracts from different parts of A. crassiflora, such as antioxidant and antiglycation properties [12,13], nematicidal, antibacterial, and larvicidal activities [14,15], and antimutagenic and antitumoral potential [11]. The fruit peel of A. crassiflora has been recently shown by our group as an exceptional source of polyphenols and alkaloids [13,16]. Based on a liquid-liquid partitioning of its ethanol extract and HPLC-ESI-MS/MS analysis, most of the polyphenols such as chlorogenic acid, epi-catechin, procyanidins B2 and C1, quercetin-glucosides, caffeoyl-hexosides, feruloyl-hexosides, and kaempferol-hexosides were concentrated and identified in the ethyl acetate and n-butanol fractions (▶ Fig.…”

Section: Pro-fibrogenic and Anti-inflammatory Potential Of A Polyphenmentioning

confidence: 96%

Pro-Fibrogenic and Anti-Inflammatory Potential of a Polyphenol-Enriched Fraction from Annona crassiflora in Skin Repair

et al. 2018

View full text Add to dashboard Cite

A polyphenol-enriched fraction from Annona crassiflora fruit peel (PEF-Ac) containing chlorogenic acid, epi-catechin, procyanidins B2 and C1, quercetin-glucoside, kaempferol, and caffeoyl-glucoside was investigated for its anti-inflammatory, pro-angiogenic, and profibrogenic potential in the healing of cutaneous wounds. Four wounds were performed on the back of C57 mice and the lesions were treated with the vehicle (Vaseline and lanolin) and PEF-Ac at concentrations of 2%, 4%, and 6% for 4 and 7 d. Neutrophils and macrophages activities were evaluated indirectly by the activity of myeloperoxidase and N-acetyl-β-D-glycosaminidase, angiogenesis was evaluated by hemoglobin dosing and vessel count in histological sections, and collagen deposition was assessed from histological sections stained with picrosirius red. PEF-Ac demonstrated anti-inflammatory activity, with reduced activities of neutrophil and macrophage in the cutaneous wounds. In addition, there was an increase in the synthesis of types I and III collagen, as well as in the percentage of wound closure, mainly after 4 d of treatment. On the other hand, PEF-Ac did not present an effective pro-angiogenic activity. A. crassiflora fruit peel showed anti-inflammatory and profibrogenic properties, indicating a promising natural source of bioactive molecules for treatment of cutaneous wounds.

show abstract

“…Letras iguais indicam diferença não significativa (p < 0.05). DE GOUVEIA et al, 2014;PEREIRA et al, 2017).…”

Section: Figuraunclassified

Avaliação da capacidade antioxidante e antiglicante de plantas medicinais e seu potencial de inibição das enzimas digestivas relacionadas ao diabetes mellitus tipo 2

Franco

View full text Add to dashboard Cite

Some medicinal plants are able to providing antioxidant compounds that act against oxidative stress and protein glycation and others that are capable of inhibiting the catalysis of digestive enzymes and thus possibly contributing to the reduction of postprandial hyperglycemia and hyperlipidemia. Our objective was to investigate the antioxidant and anti-glycation activities of some medicinal plants and their potential inhibitory against α-amylase, α-glucosidase and pancreatic lipase activities. Based on the ethnobotanical researches carried out by academic studies conducted at the Federal University of Uberlandia, ten plants traditionally used in the treatment of type-2 diabetes mellitus were selected. Ethanol (ETOH) and hexane (Hex) extracts of specific parts of these plants were used in enzymatic assays to evaluate their inhibitory potential against α-amylase, α-glucosidase and lipase, as well as their antioxidant (DPPH, ORAC and FRAP) and anti-glycation (BSA/fructose model) capacities. The results indicate that ETOH extract of four of the ten analyzed plants exhibited more than 70% of antioxidant and anti-glycation capacities, and α-amylase and lipase inhibitory activities; no extract was able to inhibit more than 40% the αglucosidase activity. The ETOH extracts of Bauhinia forficata and Syzygium cumini inhibited α-amylase, while the ETOH extracts of B. forficata, Matricaria recutita and Echinodorus grandiflorus inhibited lipase. In addition, the ETOH extracts of B. forficata, S. cumini, M. recutita and E. grandiflorus presented higher antioxidant capacity, respectively. and anti-graft activity. ETOH extracts from four of the ten species popularly cited for treatment of type 2 diabetes mellitus showed promising antioxidant and anti-glycating properties as well as ability to inhibit α-amylase and lipase digestive enzymes. The partitions of B. forficata and S. cumini showed prominent results in all trials. Thus, our results open new possibilities for others studies, to evaluate the antidiabetic potential of these medicinal plants.

show abstract

Stephalagine, an alkaloid with pancreatic lipase inhibitory activity isolated from the fruit peel of Annona crassiflora Mart.

Cited by 41 publications

References 29 publications

Causes and solutions to “globesity”: The new fa(s)t alarming global epidemic

Causes and solutions to “globesity”: The new fa(s)t alarming global epidemic

Pro-Fibrogenic and Anti-Inflammatory Potential of a Polyphenol-Enriched Fraction from Annona crassiflora in Skin Repair

Avaliação da capacidade antioxidante e antiglicante de plantas medicinais e seu potencial de inibição das enzimas digestivas relacionadas ao diabetes mellitus tipo 2

Contact Info

Product

Resources

About