Stepchild of American Pediatrics: Child Transportation Safety

Charles, Seymour

doi:10.3928/0090-4481-19771101-09

Cited by 2 publications

(2 citation statements)

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“…Key physiological differences in the brains of children include ongoing myelination and synaptogenesis [21], generally greater cerebral blood flow and oxygen consumption until adolescence [22,23], increased brain water content [24], and less elastic brain parenchyma [25]. Gross anatomical differences, notably a larger head relative to body size [26] and lower center of gravity [27], also increase pediatric susceptibility and influence outcomes related to TBI ( Figure 2). anatomical differences, notably a larger head relative to body size [26] and lower center of gravity [27], also increase pediatric susceptibility and influence outcomes related to TBI ( Figure 2).…”

Section: Pediatric Tbi-different Than Adultsmentioning

confidence: 99%

“…Gross anatomical differences, notably a larger head relative to body size [26] and lower center of gravity [27], also increase pediatric susceptibility and influence outcomes related to TBI ( Figure 2). anatomical differences, notably a larger head relative to body size [26] and lower center of gravity [27], also increase pediatric susceptibility and influence outcomes related to TBI ( Figure 2). In pre-clinical studies, pediatric TBI has been modeled using a variety of animals, type of TBI, age at time of injury, post-injury analysis time points, behavioural tests, and molecular markers, in an effort to more clearly define how the developing brain responds to injury.…”

Section: Pediatric Tbi-different Than Adultsmentioning

confidence: 99%

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Neuro-Inflammation in Pediatric Traumatic Brain Injury—from Mechanisms to Inflammatory Networks

Fraunberger

Esser

2019

Brain Sciences

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Compared to traumatic brain injury (TBI) in the adult population, pediatric TBI has received less research attention, despite its potential long-term impact on the lives of many children around the world. After numerous clinical trials and preclinical research studies examining various secondary mechanisms of injury, no definitive treatment has been found for pediatric TBIs of any severity. With the advent of high-throughput and high-resolution molecular biology and imaging techniques, inflammation has become an appealing target, due to its mixed effects on outcome, depending on the time point examined. In this review, we outline key mechanisms of inflammation, the contribution and interactions of the peripheral and CNS-based immune cells, and highlight knowledge gaps pertaining to inflammation in pediatric TBI. We also introduce the application of network analysis to leverage growing multivariate and non-linear inflammation data sets with the goal to gain a more comprehensive view of inflammation and develop prognostic and treatment tools in pediatric TBI.

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