Step By Step Free Flap Training Based on Inferior Superficial Epigastric Vessels in Rats

Abstract

Results: During acute allograft rejection, we identified a differential transmigration pattern of monocyte subsets by intravital imaging. We found non-classical monocytes to be pro-inflammatory and infiltrate the allograft primarily. CRP significantly increased activation and cytokine expression of this monocyte subset, thus accelerating clinical allograft rejection. Conclusion:Non-classical monocytes primarily infiltrate allogeneic tissue and contribute to acute rejection after allogeneic transplantation. Differential activation of these cells by CRP aggravates innate immune response and accelerates clinical allograft rejection, thus representing potential targets for immunomodulatory therapies.