Stenotrophomonas maltophilia: the significance and role as a nosocomial pathogen

Şenol, Esin

doi:10.1016/j.jhin.2004.01.033

Cited by 128 publications

(127 citation statements)

References 55 publications

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“…S2). These two bacteria are considered to be nosocomial pathogens with low levels of virulence in the natural cohabitation state (35,36). It has also been reported that they spontaneously emerge in immunocompromised cancer patients in the absence of contamination from their surrounding environment (37,38).…”

Section: Discussionmentioning

confidence: 99%

Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosal antibody-mediated symbiosis

Obata

Goto

Kunisawa

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

201

185

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The indigenous bacteria create natural cohabitation niches together with mucosal Abs in the gastrointestinal (GI) tract. Here we report that opportunistic bacteria, largely Alcaligenes species, specifically inhabit host Peyer's patches (PPs) and isolated lymphoid follicles, with the associated preferential induction of antigen-specific mucosal IgA Abs in the GI tract. Alcaligenes were identified as the dominant bacteria on the interior of PPs from naïve, specific-pathogen-free but not from germ-free mice. Oral transfer of intratissue uncultured Alcaligenes into germ-free mice resulted in the presence of Alcaligenes inside the PPs of recipients. This result was further supported by the induction of antigen-specific Ab-producing cells in the mucosal (e.g., PPs) but not systemic compartment (e.g., spleen). The preferential presence of Alcaligenes inside PPs and the associated induction of intestinal secretory IgA Abs were also observed in both monkeys and humans. Localized mucosal Ab-mediated symbiotic immune responses were supported by Alcaligenes-stimulated CD11c + dendritic cells (DCs) producing the Ab-enhancing cytokines TGF-β, B-cell-activating factor belonging to the TNF family, and IL-6 in PPs. These CD11c + DCs did not migrate beyond the draining mesenteric lymph nodes. In the absence of antigen-specific mucosal Abs, the presence of Alcaligenes in PPs was greatly diminished. Thus, indigenous opportunistic bacteria uniquely inhabit PPs, leading to PP-DCsinitiated, local antigen-specific Ab production; this may involve the creation of an optimal symbiotic environment on the interior of the PPs.Alcaligenes | intratissue habitation | Peyer's patch

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Section: Discussionmentioning

confidence: 99%

Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosal antibody-mediated symbiosis

Obata

Goto

Kunisawa

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

201

185

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“…Three species of the genus Acinetobacter were detected in four of five samples and Stenotrophomonas maltophilia was detected in two of five samples; both genera cause a variety of fatal systemic infections in immunocompromised subjects, such as bacteraemia, pneumonia, endocarditis and pyelonephritis (Bergogne-Bérézin & Towner, 1996;Senol, 2004;Vartivarian et al, 1996). Since they are ubiquitous in the environment, e.g.…”

Section: Bacterial Speciesmentioning

confidence: 99%

“…Since they are ubiquitous in the environment, e.g. in soil, tap water and crops (Seifert et al, 1997;Senol, 2004), these genera are able to survive harsh environmental conditions that occur through a wide range of physical and chemical changes. As a result, they may be able to survive the rapidly changing conditions of the surface of the skin.…”

Section: Bacterial Speciesmentioning

confidence: 99%

Detection of potentially novel bacterial components of the human skin microbiota using culture-independent molecular profiling

Dekio

Hayashi

Sakamoto

et al. 2005

Journal of Medical Microbiology

131

116

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Although the micro-organisms forming the cutaneous microbiota are considered to play important roles in the modification and prevention of skin diseases, a comprehensive analysis of their composition has not yet been carried out because of difficulties in determining yet-to-be-cultured micro-organisms in the samples. Swab-scrubbed forehead skin samples of five healthy volunteers were analysed by profiling 16S rRNA genes, as well as by conventional culture methods, to provide a profile of the cutaneous microbiota that included yet-to-be-cultured bacteria from normal human skin. Cluster analyses of the 16S rRNA gene sequences indicated a marked increase in diversity compared with that derived from the culture methods. Nineteen previously recognized species and 13 novel phylotypes were obtained from the analysis of 416 clones. In addition to well-known bacteria such as Staphylococcus epidermidis and Propionibacterium acnes, phylotype A, the 16S rRNA gene of which is 97 % similar to that of Methylophilus methylotrophus, was detected in three of the five samples, in one of which it was the predominant clone. Culture-independent genetic profiling of 16S rRNA genes for detecting human cutaneous microbiota has allowed us to detect potentially novel components of the cutaneous microbiota in humans.

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“…Türkiye'den yapılan çalış-malar irdelendiğinde, S. maltophilia genel hastane infeksiyonu etkeni olarak %0-1.6 oranları arasında izole edilmekte ve bu oran YBÜ (Yoğun Bakım Ünitesi) kökenlerinde %4'lere kadar çıkabilmektedir [3][4][5]. Yurt içi ve yurt dışı çalışmaların çoğunda, pnömoni ve bakteremi en sık saptanan ve mortalitesi yüksek olan infeksiyonlar olarak bildirilmektedir [1,2,4,6]. SENTRY Antimikrobiyal Sürveyans Program çalışmasında Kanada, Amerika Birleşik Devletleri, Latin Amerika, Avrupa ve Asya Pasifik'ten 842 S. maltophilia izolatının etken olduğu infeksiyonda pnömoni görülme oranının bakteriemilere göre dört kat daha fazla olduğu saptanmıştır [6].…”

Section: Discussionunclassified

Stenotrophomonas maltophilia as a Pathogen of Nosocomial Pneumonia: Seven Case Reports

Özdemır¹,

Özdemir²,

Havlucu³

2013

Tur Toraks Der

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Stenotrophomonas maltophilia: the significance and role as a nosocomial pathogen

Cited by 128 publications

References 55 publications

Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosal antibody-mediated symbiosis

Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosal antibody-mediated symbiosis

Detection of potentially novel bacterial components of the human skin microbiota using culture-independent molecular profiling

Stenotrophomonas maltophilia as a Pathogen of Nosocomial Pneumonia: Seven Case Reports

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