Stenotrophomonas maltophilia bacteremia and pneumonia at a tertiary-care oncology center: a review of 16 years

Velázquez-Acosta, Consuelo; Zarco-Márquez, Sugehily; Jiménez-Andrade, Mari Carmen; Volkow-Fernández, Patricia; Cornejo‐Juárez, Patricia

doi:10.1007/s00520-017-4032-x

Cited by 29 publications

(33 citation statements)

References 17 publications

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“…In the US, S. maltophilia accounted for 5.1-6.8% of the aetiologies of overall HAP episodes from 2015 through 2017 [18,19]. For S. maltophilia pneumonia, an age ≥65 years-old and receipt of therapy with inappropriate antibiotics were identified as risk factors associated with 30-day mortality amongst patients with cancer [50]. In addition, a Taiwanese study investigating 406 patients with pneumonia caused by S. maltophilia observed that only approximately 60% of the enrolled patients ever stayed in the ICU or had a ≥28-day hospital stay before the onset of S. maltophilia pneumonia [50].…”

Section: Esbl-and Xdr-enterobacteriaceae Speciesmentioning

confidence: 99%

“…For S. maltophilia pneumonia, an age ≥65 years-old and receipt of therapy with inappropriate antibiotics were identified as risk factors associated with 30-day mortality amongst patients with cancer [50]. In addition, a Taiwanese study investigating 406 patients with pneumonia caused by S. maltophilia observed that only approximately 60% of the enrolled patients ever stayed in the ICU or had a ≥28-day hospital stay before the onset of S. maltophilia pneumonia [50]. Moreover, in that Taiwanese study, about one half of these patients received mechanical ventilator support, whilst one quarter of the patients with S. maltophilia pneumonia had malignancy, diabetes mellitus, or chronic respiratory disorders [51].…”

Section: Esbl-and Xdr-enterobacteriaceae Speciesmentioning

confidence: 99%

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Epidemiology, Treatment, and Prevention of Nosocomial Bacterial Pneumonia

Jean

Chang

Wei

et al. 2020

JCM

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Septicaemia likely results in high case-fatality rates in the present multidrug-resistant (MDR) era. Amongst them are hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP), two frequent fatal septicaemic entities amongst hospitalised patients. We reviewed the PubMed database to identify the common organisms implicated in HAP/VAP, to explore the respective risk factors, and to find the appropriate antibiotic choice. Apart from methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa, extended-spectrum β-lactamase-producing Enterobacteriaceae spp., MDR or extensively drug-resistant (XDR)-Acinetobacter baumannii complex spp., followed by Stenotrophomonas maltophilia, Chryseobacterium indologenes, and Elizabethkingia meningoseptica are ranked as the top Gram-negative bacteria (GNB) implicated in HAP/VAP. Carbapenem-resistant Enterobacteriaceae notably emerged as an important concern in HAP/VAP. The above-mentioned pathogens have respective risk factors involved in their acquisition. In the present XDR era, tigecycline, colistin, and ceftazidime-avibactam are antibiotics effective against the Klebsiella pneumoniae carbapenemase and oxacillinase producers amongst the Enterobacteriaceae isolates implicated in HAP/VAP. Antibiotic combination regimens are recommended in the treatment of MDR/XDR-P. aeruginosa or A. baumannii complex isolates. Some special patient populations need prolonged courses (>7-day) and/or a combination regimen of antibiotic therapy. Implementation of an antibiotic stewardship policy and the measures recommended by the United States (US) Institute for Healthcare were shown to decrease the incidence rates of HAP/VAP substantially.

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Section: Esbl-and Xdr-enterobacteriaceae Speciesmentioning

confidence: 99%

Section: Esbl-and Xdr-enterobacteriaceae Speciesmentioning

confidence: 99%

Epidemiology, Treatment, and Prevention of Nosocomial Bacterial Pneumonia

Jean

Chang

Wei

et al. 2020

JCM

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“…One study estimated the nosocomial mortality rates attributed to S. maltophilia bacteremia at 16.7%, and the overall mortality rate of patients infected with S. maltophilia was 25% ( Naidu and Smith, 2012 ). A recent study on the clinical outcomes of cancer patients with bloodstream infections (BSI) and pneumonia caused by S. maltophilia infections in Mexico City indicated that 31.6% died within the first month; 22.1% of the deaths were due to pneumonia and 9.5% were due to BSI ( Velazquez-Acosta et al, 2018 ). A similar study on BSI mortality rates associated with 937 German intensive care units found S. maltophilia infections had the highest mortality rates (28.4%), followed next by non- albicans - Candida spp.…”

Section: Introductionmentioning

confidence: 99%

“…Innate antibiotic resistance in S. maltophilia infections is a major contributing factor to treatment failure. Patients who receive the wrong antibiotic at initial infection diagnosis have an increased risk of mortality compared to patients who received appropriate S. maltophilia antibiotic treatment initially ( Velazquez-Acosta et al, 2018 ). S. maltophilia infections can be further complicated by the emergence of mutants with pleiotropic antibiotic resistance ( Denton and Kerr, 1998 ).…”

Section: Introductionmentioning

confidence: 99%

Characterization of Novel Broad-Host-Range Bacteriophage DLP3 Specific to Stenotrophomonas maltophilia as a Potential Therapeutic Agent

2020

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A novel Siphoviridae phage specific to the bacterial species Stenotrophomonas maltophilia was isolated from a pristine soil sample and characterized as a second member of the newly established Delepquintavirus genus. Phage DLP3 possesses one of the broadest host ranges of any S. maltophilia phage yet characterized, infecting 22 of 29 S. maltophilia strains. DLP3 has a genome size of 96,852 bp and a G+C content of 58.4%, which is significantly lower than S. maltophilia host strain D1571 (G+C content of 66.9%). The DLP3 genome encodes 153 coding domain sequences covering 95% of the genome, including five tRNA genes with different specificities. The DLP3 lysogen exhibits a growth rate increase during the exponential phase of growth as compared to the wild type strain. DLP3 also encodes a functional erythromycin resistance protein, causing lysogenic conversion of the host D1571 strain. Although a temperate phage, DLP3 demonstrates excellent therapeutic potential because it exhibits a broad host range, infects host cells through the S. maltophilia type IV pilus, and exhibits lytic activity in vivo. Undesirable traits, such as its temperate lifecycle, can be eliminated using genetic techniques to produce a modified phage useful in the treatment of S. maltophilia bacterial infections.

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“…The prevalence of nosocomial infections caused by a Gramnegative opportunistic pathogen, Stenotrophomonas maltophilia, has remarkably increased in recent years [1][2][3][4][5][6][7]. S. maltophilia is ubiquitously widespread in the water, soil, plants, animals, and foods [8,9].…”

Section: Introductionmentioning

confidence: 99%

Twitching motility of Stenotrophomonas maltophilia under iron limitation: In-silico, phenotypic and proteomic approaches

Kalidasan

Neela

2020

Virulence

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This study investigates the twitching ability of 28 clinical and five environmental strains of S. maltophilia grown under iron-depleted condition through in-silico, phenotypic and proteomics approaches. Rapid Annotations using Subsystem Technology (RAST) analysis revealed the presence of 21 targets of type IV pilus shared across S. maltophilia strains K279a, R551-3, D457 and JV3. The macroscopic twitching assay showed that only clinical isolates produced a zone of twitching with a mean of 22.00 mm under normal and 25.00 mm under iron-depleted conditions. (p = 0.002). Environmental isolates did not show any significant twitching activity in both conditions tested. Isobaric Tags for Relative and Absolute Quantification (ITRAQ) analysis showed altered expression of twitching motility protein PilT (99.08-fold change), flagellar biosynthesis protein FliC (20.14-fold change), and fimbrial protein (0.70-fold change) in response to iron-depleted condition. Most of the strains that have the ability to twitch under the normal condition, exhibit enhanced twitching during iron limitation. ARTICLE HISTORY

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Stenotrophomonas maltophilia bacteremia and pneumonia at a tertiary-care oncology center: a review of 16 years

Abstract: S. maltophilia related with ambulatory CRBSI have a better prognosis than other sources of BSI. Older patients with pneumonia who do not receive appropriate antibiotics have higher mortality. SMX/TMP is still the antibiotic of choice.

Cited by 29 publications

References 17 publications

Epidemiology, Treatment, and Prevention of Nosocomial Bacterial Pneumonia

Epidemiology, Treatment, and Prevention of Nosocomial Bacterial Pneumonia

Characterization of Novel Broad-Host-Range Bacteriophage DLP3 Specific to Stenotrophomonas maltophilia as a Potential Therapeutic Agent

Twitching motility of Stenotrophomonas maltophilia under iron limitation: In-silico, phenotypic and proteomic approaches

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