Stenotrophomonas africana Drancourt et al. 1997 is a later synonym of Stenotrophomonas maltophilia (Hugh 1981) Palleroni and Bradbury 1993

Coenye, Tom; Vanlaere, Elke; Falsen, Enevold; Vandamme, Peter

doi:10.1099/ijs.0.63093-0

Cited by 41 publications

(26 citation statements)

References 14 publications

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“…At present, this genus is comprised of nine species, five of which, S. dokdonensis, S. humi, S. koreensis, S. rhizophila, and S. terrae, were not available for the study presented here. The delineation of S. africana from S. maltophilia has been debated (10,21). This work also confirms that S. africana is a synonym for S. maltophilia.…”

Section: Discussionsupporting

confidence: 74%

A Stenotrophomonas maltophilia Multilocus Sequence Typing Scheme for Inferring Population Structure

2009

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Stenotrophomonas maltophilia is an opportunistic, highly resistant, and ubiquitous pathogen. Strains have been assigned to genogroups using amplified fragment length polymorphism. Hence, isolates of environmental and clinical origin predominate in different groups. A multilocus sequence typing (MLST) scheme was developed using a highly diverse selection of 70 strains of various ecological origins from seven countries on all continents including strains of the 10 previously defined genogroups. Sequence data were assigned to 54 sequence types (ST) based on seven loci. Indices of association for all isolates and clinical isolates of 2.498 and 2.562 indicated a significant linkage disequilibrium, as well as high congruence of tree topologies from different loci. Potential recombination events were detected in one-sixth of all ST. Calculation of the mean divergence between and within predicted clusters confirmed previously defined groups and revealed five additional groups. Consideration of the different ecological origins showed that 18 out of 31 respiratory tract isolates, including 12 out of 19 isolates from cystic fibrosis (CF) patients, belonged to genogroup 6. In contrast, 16 invasive strains isolated from blood cultures were distributed among nine different genogroups. Three genogroups contained isolates of strictly environmental origin that also featured high sequence distances to other genogroups, including the S. maltophilia type strain. On the basis of this MLST scheme, isolates can be assigned to the genogroups of this species in order to further scrutinize the population structure of this species and to unravel the uneven distribution of environmental and clinical isolates obtained from infected, colonized, or CF patients.Stenotrophomonas maltophilia is ubiquitous in nature. It has, for instance, been isolated from the rhizosphere of various plants and animals (14, 27, 37). Due to its tolerance against cadmium and its ability to degrade xenobiotic compounds, it has been proposed for remediation of contaminated ground (9, 39). Increasingly, it is being isolated from immunosuppressed individuals and intensive care and cystic fibrosis (CF) patients and has been shown to be resistant to many antimicrobial agents (16,17,69). However, the role of this opportunistic pathogen as an innocent bystander or causative agent often remains unclear (30), and little is known about its virulence factors (20,33).Recently, novel Stenotrophomonas species were described: Stenotrophomonas nitritireducens sp. nov. (24), Stenotrophomonas acidaminiphila (3), Stenotrophomonas rhizophila (73), and Stenotrophomonas africana sp. nov. (21). However, the latter is a synonym of S. maltophilia (10).Using amplified fragment length polymorphism (AFLP) fingerprinting and DNA-DNA hybridizations, remarkable diversity has been shown to exist among S. maltophilia isolates recovered from both the environment and human clinical samples. This species can be subdivided into 10 AFLP genomic groups (35) that comprise to various extents both clinical ...

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Section: Discussionsupporting

confidence: 74%

A Stenotrophomonas maltophilia Multilocus Sequence Typing Scheme for Inferring Population Structure

2009

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“…Cluster analysis of the gyrB RFLP patterns of studied Stenotrophomonas isolates revealed 9 different clusters, while several strains showed distinct and unique patterns (Coenye et al, 2004a(Coenye et al, , 2004b. The majority of CF isolates are grouped in 2 clusters, named B and C, thus suggesting that specific genomic groups have an increased potential for colonization of the respiratory tract of CF patients (Coenye et al, 2004a(Coenye et al, , 2004b.…”

Section: Rflp Analysismentioning

confidence: 95%

“…S. dokdonensis was recently moved to a different genus (Lee et al, 2008;Yoon et al, 2006). S. africana, which had been considered as a new species in 1997, was later found to be synonymous to S. maltophilia (Coenye et al, 2004a;Drancourt et al, 1997). Stenotrophomonas spp.…”

Section: Introductionmentioning

confidence: 98%

An overview of various typing methods for clinical epidemiology of the emerging pathogen Stenotrophomonas maltophilia

Gherardi¹,

Creti²,

Pompilio³

et al. 2015

Diagnostic Microbiology and Infectious Disease

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“…maltophilia is the only species of Stenotrophomonas known to cause human disease (40). S. maltophilia has significant resistance to broad-spectrum antibiotics, resulting in limited treatment options (2,3,6).…”

Section: Discussionmentioning

confidence: 99%

Characterization of Maltocin P28, a Novel Phage Tail-Like Bacteriocin from Stenotrophomonas maltophilia

Liu

Chen

Zheng

et al. 2013

Appl Environ Microbiol

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bStenotrophomonas maltophilia is an important global opportunistic pathogen for which limited therapeutics are available because of the emergence of multidrug-resistant strains. A novel bacteriocin, maltocin P28, which is produced by S. maltophilia strain P28, may be the first identified phage tail-like bacteriocin from S. maltophilia. Maltocin P28 resembles a contractile but nonflexible phage tail structure based on electron microscopy, and it is sensitive to trypsin, proteinase K, and heat. SDS-PAGE analysis of maltocin P28 revealed two major protein bands of approximately 43 and 20 kDa. The N-terminal amino acid residues of these two major subunits were sequenced, and the maltocin P28 gene cluster was located on the S. maltophilia P28 chromosome. Our sequence analysis results indicate that this maltocin gene cluster consists of 23 open reading frames (ORFs), and that its gene organization is similar to that of the P2 phage genome and R2 pyocin gene cluster. ORF17 and ORF18 encode the two major structural proteins, which correspond to gpFI (tail sheath) and gpFII (tail tube) of P2 phage, respectively. We found that maltocin P28 had bactericidal activity against 38 of 81 tested S. maltophilia strains. Therefore, maltocin P28 is a promising therapeutic substitute for antibiotics for S. maltophilia infections.

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Stenotrophomonas africana Drancourt et al. 1997 is a later synonym of Stenotrophomonas maltophilia (Hugh 1981) Palleroni and Bradbury 1993

Cited by 41 publications

References 14 publications

A Stenotrophomonas maltophilia Multilocus Sequence Typing Scheme for Inferring Population Structure

A Stenotrophomonas maltophilia Multilocus Sequence Typing Scheme for Inferring Population Structure

An overview of various typing methods for clinical epidemiology of the emerging pathogen Stenotrophomonas maltophilia

Characterization of Maltocin P28, a Novel Phage Tail-Like Bacteriocin from Stenotrophomonas maltophilia

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