Stem/progenitor cells: A potential source of retina-specific cells for retinal repair

Bi, Yongyan; Feng, Donghan; Pan, Dong-chao

doi:10.1016/j.neures.2009.07.008

Cited by 22 publications

(22 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, allotransplants of fetal or postmortem tissue lead to rejection and the need to apply immunosuppressants and, at the same time, they raise moral and ethical concerns [30,45]. These problems are partially eliminated by the cell transplant concept [45,48]. …”

Section: Tissue Therapy In Retinal Diseasesmentioning

confidence: 99%

Ophthalmic transplantology: Posterior segment of the eye – Part II

Nita¹,

Strzałka‐Mrozik

Grzybowski

et al. 2012

Med Sci Monit

View full text Add to dashboard Cite

SummaryBackgroundTransplants of the retina are among the new strategies being used in the treatment of genetic and degenerative macular diseases. Moreover, various cell cultures are being tested to treat retinal disorders.Material/MethodsLiterature dated from 2004 to 2011 was comprehensively examined via Medline and PubMed searches for the following terms: auto-, homo-, heterologous transplantation, retina, stem cells, cultivated cells.ResultsTissue and cell therapy of retinal diseases are reviewed, including full-thickness retina/retinal pigment epithelium (RPE)/choroid graft; full and partial thickness RPE/choroid complex grafts; RPE/Bruch membrane complex graft; and RPE, iris pigment epithelium and stem cell grafts. Recommendations for transplants, as well as the benefits and weaknesses of specific techniques in retina transplants, are discussed.ConclusionsAuto- and allogenic transplants of a full or partial thickness retina/RPE/Bruch membrane/choroid complex represent an alternative treatment offered to patients with some macular diseases. Stem cell transplantation to reconstruct and regenerate the macula requires further biomolecular and animal research studies.

show abstract

Section: Tissue Therapy In Retinal Diseasesmentioning

confidence: 99%

Ophthalmic transplantology: Posterior segment of the eye – Part II

Nita¹,

Strzałka‐Mrozik

Grzybowski

et al. 2012

Med Sci Monit

View full text Add to dashboard Cite

show abstract

“…The integrity of the inner retina is a prerequisite for most of the approaches aimed at restoring vision, such as vectorbased gene therapy (Bennett, 2000;Auricchio and Rolling, 2005;Busskamp et al, 2010), stem or progenitor cell transplantation (Lund et al, 2003;MacLaren et al, 2006;Bi et al, 2009;Pearson et al, 2012), and implantation of prosthetic devices (Zrenner, 2002;Viola and Patrinos, 2007;Chader et al, 2009).…”

mentioning

confidence: 99%

Functional and neurochemical development in the normal and degenerating mouse retina

Gibson

Fletcher

Vingrys

et al. 2013

J of Comparative Neurology

View full text Add to dashboard Cite

The rd1 mouse is a well-established animal model for human retinitis pigmentosa (RP). We used electroretinography (ERG) to evaluate retinal function and postembedding immunocytochemistry to determine the changes in cellular amino acid expression in the normal (C57Bl6) and degenerating mouse retina (rd1), as a function of age during development and the onset of degeneration. In the normal mouse retina, photoreceptoral and post-photoreceptoral ERG responses improved simultaneously from eye-opening until adult levels were achieved at approximately postnatal day (P) 30. Maturation of amino acid neurochemistry preceded the development of retinal function in the normal retina. Amino acid levels increased immediately from birth and reached stable levels by eye-opening. In contrast, in the rd1 mouse, both rod and cone pathway function rapidly reduced from eye-opening and by P21 became undetectable. Interestingly, at P18 cone responses were still comparable between the normal and degenerating retina. Before eye opening, the pattern of amino acid immunoreactivity in the rd1 retina was similar to the normal retina. Alterations in neurochemistry were observed after the onset of rod photoreceptor cell death. The most obvious change was the reduction in neurotransmitter immunoreactivity within the synaptic layers and some cell classes of the rd1 retina. Reduction of glutamine and glutamate was observed in Müller cells before established gliosis markers. Overall, these results suggest the rapid maturation of neurochemistry by eye opening followed by functional maturation by P30 in the normal retina. The dystrophic retina displays similar neurochemistry to control retina before eye opening but a subsequent decline. J. Comp. Neurol. 521:1251-1267, 2013

show abstract

“…In 2004, Ooto and colleagues proved the capacity of Muller glia cells to generate retinal neurons. Successively, an accurate analysis of gene expression in retinal precursors and Muller glia cells confirms an overlap between the profile of these two cell types and the potentiality of Muller glia cells as neural stem cells Bi et al, 2009). Transdifferentition of RPE cells into neural retina has been demonstrated in embryonic rat after the treatment with growth factors such as basic FGFs (Ballios & Van der Kooy, 2010).…”

Section: Mammalsmentioning

confidence: 84%

“…Moreover, if cultured in vitro, they are able to generate retinal neurons. Similarly, the iris epithelium cells, which derive from the inner layer of iris tissue, express nestin (stem cells marker) and possess the ability to differentiate in multiple neuronal types including retinal neurons (Bi et al;2009). Analyses in Mammals reveal that ciliary body and iris stem cells express Pax6, Rax, Chx10 and Six3, thus supporting the idea of retinal precursors properties and a conserved molecular mechanism in retinal stem cells generation among vertebrates (Locker et al, 2009).…”

Section: Mammalsmentioning

confidence: 85%