Stem Cells, Tissue Engineering and Regenerative Medicine

Warburton, David

doi:10.1142/9212

Cited by 3 publications

(2 citation statements)

References 44 publications

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“…IL-6 cytokine families are structurally and functionally linked. They act on different cells, actually, they are pleiotropic and can mediate proliferation or differentiation or both, according to target cell types (1,22,28,29,(34)(35)(36)(37).…”

Section: The Importance Of "Feeder" Cells Growth Factors and Serum-fmentioning

confidence: 99%

Embryonic Stem Cells: Where Do We Stand at the Moment?

Raščanin¹,

Rančić²,

Dragović³

et al. 2019

amm

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Stem cells are functionally defined as cells that have the ability to self-replicate and generate differentiated cells. They can generate multiple differentiated cell types (multipotent or pluripotent) or produce one type of differentiated cells (unipotent) depending on the replication capacity and potency of stem cells. Today stem cells might have potential application in regenerative medicine, transplantation, treatment of autoimmune, chronic and progressive diseases, as well as disease modelling. Now we are faced with a dilemma between the two types of stem cells, which are more suitable for research and therapeutic use, which will be Embryonic Stem Cells (ESC) or Induced Pluripotent Stem Cells (iPSC)? ESCs represent the gold standard of pluripotency in vitro, which compares all other types of stem cells, but iPSC are more convenient in autologous transplants because of the avoidance of tissue rejection and without ethical concerns. The aim of this paper is presenting the most important characteristics of the ESCs which have therapeutic significance.

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Section: The Importance Of "Feeder" Cells Growth Factors and Serum-fmentioning

confidence: 99%

Embryonic Stem Cells: Where Do We Stand at the Moment?

Raščanin¹,

Rančić²,

Dragović³

et al. 2019

amm

View full text Add to dashboard Cite

show abstract

“…By expanding the range of genetic backgrounds to include any donor (e.g. patient-specific), reprogrammed cells fundamentally alter the possibilities for modeling diseases at the cellular level [ 6 ]. Relevant disease phenotypes have already been captured in reprogrammed cells, suggesting the potential to use these cells as a tool to study neurological, muscular, and cardiac diseases [ 7 – 12 ].…”

Section: Introduction To Cellular Reprogrammingmentioning

confidence: 99%

Engineering cell fate: Applying synthetic biology to cellular reprogramming

Wang¹,

Beitz²,

Galloway³

2020

Current Opinion in Systems Biology

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Biomedical Applications of Recombinant Silk‐Based Materials

Aigner

DeSimone

Scheibel³

2018

Advanced Materials

238

203

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Silk is mostly known as a luxurious textile, which originates from silkworms first cultivated in China. A deeper look into the variety of silk reveals that it can be used for much more, in nature and by humanity. For medical purposes, natural silks were recognized early as a potential biomaterial for surgical threads or wound dressings; however, as biomedical engineering advances, the demand for high-performance, naturally derived biomaterials becomes more pressing and stringent. A common problem of natural materials is their large batch-to-batch variation, the quantity available, their potentially high immunogenicity, and their fast biodegradation. Some of these common problems also apply to silk; therefore, recombinant approaches for producing silk proteins have been developed. There are several research groups which study and utilize various recombinantly produced silk proteins, and many of these have also investigated their products for biomedical applications. This review gives a critical overview over of the results for applications of recombinant silk proteins in biomedical engineering.

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Stem Cells, Tissue Engineering and Regenerative Medicine

Cited by 3 publications

References 44 publications

Embryonic Stem Cells: Where Do We Stand at the Moment?

Embryonic Stem Cells: Where Do We Stand at the Moment?

Engineering cell fate: Applying synthetic biology to cellular reprogramming

Biomedical Applications of Recombinant Silk‐Based Materials

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