Stem cells: sources, properties, and cell types

Asal, Melis; Güven, Sinan

doi:10.1016/b978-0-08-102906-0.00007-6

Cited by 9 publications

(15 citation statements)

References 55 publications

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“…[68] Many fetal and adult tissues have been collected for MSCs. [69] The most researched and defined sources are bone marrow and adipose tissue. [68] 3.1.4.…”

Section: Adult Stem Cellsmentioning

confidence: 99%

Carbon Quantum Dots as Multi‐Purpose Nanomaterial in Stem Cell Therapy

Juybari

Faramarz

Sadeghi³

et al. 2023

Chemistry & Biodiversity

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Some issues, such as their obscure fate or low survival rate into the body during stem cell therapy, should be addressed to boost efficiency. Nanotechnology offers a suitable solution to combat such limitations. Carbon quantum dots (CQDs) are carbon-based nanomaterials and may be used as multi-purpose compounds in stem cell therapy. CQDs are excellent choices for stem cell labeling thanks to their special features such as optical properties and good biocompatibility. Besides, they can modulate the biological function of stem cells, such as their proliferation, homing ability, and differentiation properties. Considering the charismatic feature of CQDs and their broad unique effect on stem cells, the current review aims to summarize the advancements in this field. Hence, we first focused on CQDs synthesis and their applications. In the next section, the stem cell categories will be discussed, and the final part is dedicated to the recent research evaluating the impact of CQDs on stem cell therapy.

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“…[68] Many fetal and adult tissues have been collected for MSCs. [69] The most researched and defined sources are bone marrow and adipose tissue. [68] 3.1.4.…”

Section: Adult Stem Cellsmentioning

confidence: 99%

Carbon Quantum Dots as Multi‐Purpose Nanomaterial in Stem Cell Therapy

Juybari

Faramarz

Sadeghi³

et al. 2023

Chemistry & Biodiversity

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“…Organoids emerge as self-organized, multicellular, and functional miniature organs, with capacity to recapitulate healthy and diseased adult organ physiology. Induced pluripotent stem cells (iPSCs) possess the ability to differentiate into all three germ layers and make it possible to grow tissue specific organoids ( Takahashi et al, 2007 ; Lancaster and Knoblich, 2014 ; Asal and Güven, 2020 ). This potential of human iPSCs emerges as a promising tool to develop a functional lacrimal gland organoid that can recover the loss of function in lacrimal gland disorders.…”

Section: Introductionmentioning

confidence: 99%

Development of lacrimal gland organoids from iPSC derived multizonal ocular cells

Asal

Koçak

Sarı

et al. 2023

Front. Cell Dev. Biol.

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Lacrimal gland plays a vital role in maintaining the health and function of the ocular surface. Dysfunction of the gland leads to disruption of ocular surface homeostasis and can lead to severe outcomes. Approaches evolving through regenerative medicine have recently gained importance to restore the function of the gland. Using human induced pluripotent stem cells (iPSCs), we generated functional in vitro lacrimal gland organoids by adopting the multi zonal ocular differentiation approach. We differentiated human iPSCs and confirmed commitment to neuro ectodermal lineage. Then we identified emergence of mesenchymal and epithelial lacrimal gland progenitor cells by the third week of differentiation. Differentiated progenitors underwent branching morphogenesis in the following weeks, typical of lacrimal gland development. We were able to confirm the presence of lacrimal gland specific acinar, ductal, and myoepithelial cells and structures during weeks 4–7. Further on, we demonstrated the role of miR-205 in regulation of the lacrimal gland organoid development by monitoring miR-205 and FGF10 mRNA levels throughout the differentiation process. In addition, we assessed the functionality of the organoids using the β-Hexosaminidase assay, confirming the secretory function of lacrimal organoids. Finally, metabolomics analysis revealed a shift from amino acid metabolism to lipid metabolism in differentiated organoids. These functional, tear proteins secreting human lacrimal gland organoids harbor a great potential for the improvement of existing treatment options of lacrimal gland dysfunction and can serve as a platform to study human lacrimal gland development and morphogenesis.

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“…Tissue engineering focuses on the use of cells to regenerate biological tissue with the assistance of supporting structures and/or biomolecules [ 2 , 3 ]. While cell therapy focuses on the use of cell culture to improve, maintain, and/or restore the functionality of tissues and organs [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…Stem cells have been used in various sub-categories of regenerative medicine. Stem cells are undifferentiated cells able to differentiate into many types of different specialized cells and tissue [ 3 ] as well as self-renew through cell division [ 4 ]. The ability of stem cells to divide, differentiate and develop into different specialized cell types and their capacity for constant self-renewal make them ideal candidates for various kinds of stem cell based therapeutic applications [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Insights on Three Dimensional Organoid Studies for Stem Cell Therapy in Regenerative Medicine

Mulaudzi,

Abrahamse,

Crous

2023

Stem Cell Rev and Rep

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Regenerative medicine has developed as a promising discipline that utilizes stem cells to address limitations in traditional therapies, using innovative techniques to restore and repair damaged organs and tissues. One such technique is the generation of three-dimensional (3D) organoids in stem cell therapy. Organoids are 3D constructs that resemble specific organs' structural and functional characteristics and are generated from stem cells or tissue-specific progenitor cells. The use of 3D organoids is advantageous in comparison to traditional two-dimensional (2D) cell culture by bridging the gap between in vivo and in vitro research. This review aims to provide an overview of the advancements made towards regenerative medicine using stem cells to generate organoids, explore the techniques used in generating 3D organoids and their applications and finally elucidate the challenges and future directions in regenerative medicine using 3D organoids. Graphical Abstract

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Stem cells: sources, properties, and cell types

Cited by 9 publications

References 55 publications

Carbon Quantum Dots as Multi‐Purpose Nanomaterial in Stem Cell Therapy

Carbon Quantum Dots as Multi‐Purpose Nanomaterial in Stem Cell Therapy

Development of lacrimal gland organoids from iPSC derived multizonal ocular cells

Insights on Three Dimensional Organoid Studies for Stem Cell Therapy in Regenerative Medicine

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