Stem Cells — Scientific, Medical, and Political Issues

Weissman, Irving L.

doi:10.1056/nejmsb020693

Cited by 127 publications

(58 citation statements)

References 17 publications

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“…cells to enucleated unfertilized eggs (Rideout et al, 2002). However, the possible avenues open to human therapeutic cloning are compromised by biomedical ethical issues (Weissman, 2002). Using the pluripotential nature of reprogrammed somatic genomes opens up at least two possible ways in which these complex social issues can be avoided: (1) genetically tailored ES-like cells could be made by targeted elimination of the ES genome following cell hybridization with personal somatic cells, and (2) personal somatic cells could be reprogrammed directly by genetic manipulation of putative factors identified from ES cells.…”

Section: Discussionmentioning

confidence: 99%

Pluripotency of reprogrammed somatic genomes in embryonic stem hybrid cells

Tada

Morizane

Kimura

et al. 2003

Developmental Dynamics

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Section: Discussionmentioning

confidence: 99%

Pluripotency of reprogrammed somatic genomes in embryonic stem hybrid cells

Tada

Morizane

Kimura

et al. 2003

Developmental Dynamics

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“…Stem cells could be classified into two main types, based on their source of origin: Embryonic, which derived from the inner cell mass of preimplantation embryo and has the ability of constructing all three embryonic germ layers, and Adult, scattered in various tissues and organs, and has the capability of producing at least one type of differentiated functional progeny (4,(6)(7)(8)(9). Although the latter were thought to have a limited capacity, recent evidence have attested an extensive capability to generate cells of the three different lineages, like the former (10-12).…”

Section: Classification On Source Originmentioning

confidence: 99%

The Role of Wharton’s Jelly Mesenchymal Stem Cells in Skin Reconstruction

et al. 2015

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Context: Stem cell therapy, especially in the segment of mesenchymal stem cells (MSCs), is one of the most promising areas of regenerative medicine. Evidence Acquisition: According to research conducted by various researchers, Wharton's Jelly mesenchymal stem cells (WJMSCs) have several advantages compared to others sources, in regenerative medicine: WJMSCs are more primary cells; WJMSCs can be easily isolated and without invasive procedures; WJMSCs have no ethical problems; WJMSCs are more cost effective than other sources of MSCs. Also, WJMSCs were demonstrated to express stem cell mesenchymal markers. Results: Similar to bone marrow MSCs, WJMSCs express major histocompatibility complex (MHC) class I molecules. Conclusions: Although the aforementioned challenges must still be addressed, the potential of WJMSCs in skin regenerative clinical treatments is promising.

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“…Derived from the inner cell mass of the blastocyst, embryonic stem cells possess the ability to differentiate along endodermal, ectodermal, and mesodermal lineages. However, because of the ethical and political debate currently surrounding the use of embryonic stem cells, substantial efforts have been directed at characterizing alternative sources of stem cells, which maybe more limited in their multilineage potential (47,48). These include amniotic fluid, umbilical cord blood, bone marrow, subcutaneous (s.c.) fat, and dental pulp, among others (49 -53).…”

Section: A Cell-based Approachmentioning

confidence: 99%

Tissue Engineering in Cleft Palate and Other Congenital Malformations

et al. 2008

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ABSTRACT:Contributions from multidisciplinary investigations have focused attention on the potential of tissue engineering to yield novel therapeutics. Congenital malformations, including cleft palate, craniosynostosis, and craniofacial skeletal hypoplasias represent excellent targets for the implementation of tissue engineering applications secondary to the technically challenging nature and inherent inadequacies of current reconstructive interventions. Apropos to the search for answers to these clinical conundrums, studies have focused on elucidating the molecular signals driving the biologic activity of the aforementioned maladies. These investigations have highlighted multiple signaling pathways, including Wnt, fibroblast growth factor, transforming growth factor-␤, and bone morphogenetic proteins, that have been found to play critical roles in guided tissue development. Furthermore, a comprehensive knowledge of these pathways will be of utmost importance to the optimization of future cell-based tissue engineering strategies. The scope of this review encompasses a discussion of the molecular biology involved in the development of cleft palate and craniosynostosis. In addition, we include a discussion of craniofacial distraction osteogenesis and how its applied forces influence cell signaling to guide endogenous bone regeneration.

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Stem Cells — Scientific, Medical, and Political Issues

Cited by 127 publications

References 17 publications

Pluripotency of reprogrammed somatic genomes in embryonic stem hybrid cells

Pluripotency of reprogrammed somatic genomes in embryonic stem hybrid cells

The Role of Wharton’s Jelly Mesenchymal Stem Cells in Skin Reconstruction

Tissue Engineering in Cleft Palate and Other Congenital Malformations

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