Stem cells purified from human induced pluripotent stem cell-derived neural crest-like cells promote peripheral nerve regeneration

Kimura, Hiroo; Ouchi, Takehito; Shibata, Shinsuke; Amemiya, Takayuki; Nagoshi, Narihito; Nakagawa, Taneaki; Matsumoto, Morio; Nakamura, Masaya; Sato, Kazuki

doi:10.1038/s41598-018-27952-7

Cited by 44 publications

(41 citation statements)

References 54 publications

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“…The NCC‐derived MSCs were also reported to exhibit chondrogenic potential to repair osteochondral defects in vivo possibly via participation in regeneration of hyaline cartilaginous tissue . A subpopulation of NCCs derived from hiPSCs was found to promote peripheral nerve regeneration in a murine model of massive peripheral nerve defect .…”

Section: Therapeutic Effects Of Ps‐mscs In Vivomentioning

confidence: 99%

Concise Review: Mesenchymal Stem Cells Derived from Human Pluripotent Cells, an Unlimited and Quality-Controllable Source for Therapeutic Applications

Jiang¹,

Li²,

Wang³

et al. 2019

Stem Cells

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Despite the long discrepancy over their definition, heterogeneity, and functions, mesenchymal stem cells (MSCs) have proved to be a key player in tissue repair and homeostasis. Generally, somatic tissue-derived MSCs (st-MSCs) are subject to quality variations related to donated samples and biosafety concern for transmission of potential pathogens from the donors. In contrast, human pluripotent stem cells (hPSCs) are unlimited in supply, clear in the biological background, and convenient for quality control, genetic modification, and scale-up production. We, and others, have shown that hPSCs can differentiate in two dimensions or three dimensions to MSCs (ps-MSCs) via embryonic (mesoderm and neural crest) or extraembryonic (trophoblast) cell types under serum-containing or xeno-free and defined conditions. Compared to st-MSCs, ps-MSCs appear less mature, proliferate faster, express lower levels of inflammatory cytokines, and respond less to traditional protocols for st-MSC differentiation to other cell types, especially adipocytes. Nevertheless, ps-MSCs are capable of immune modulation and treatment of an increasing number of animal disease models via mitochondria transfer, paracrine, exosomes, and direct differentiation, and can be potentially used as a universal and endless therapy for clinical application. This review summarizes the progress on ps-MSCs and discusses perspectives and challenges for their potential translation to the clinic. STEM CELLS 2019;37:572-581 SIGNIFICANCE STATEMENTThis article provides a thorough and timely review of the history, progress, challenges, and perspective of mesenchymal stem cells derived from human pluripotent cells as a promising, qualitycontrollable, and unlimited source for therapeutic application.The unique advantages of ps-MSCs over st-MSCs include unlimited supply, more convenience for quality control, genetic manipulation, and scalable production, lower cost, and higher purity (Table 1). Below, we will introduce the history and latest advancements we and others have achieved in ps-MSC generation and study in vitro and in animal disease models, in comparison with st-MSCs. We will also discuss the perspectives and challenges for research and clinical application of ps-MSCs.

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Section: Therapeutic Effects Of Ps‐mscs In Vivomentioning

confidence: 99%

Concise Review: Mesenchymal Stem Cells Derived from Human Pluripotent Cells, an Unlimited and Quality-Controllable Source for Therapeutic Applications

Jiang¹,

Li²,

Wang³

et al. 2019

Stem Cells

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“…Generally, if artificial materials exist in the body for a long time, problems such as infection or degradation may arise; thus, the characteristics of type I collagen, which can be absorbed by the body, might be suitable. In addition, collagen seems to provide an effective scaffold with little toxicity, as suggested by other studies [30,31].…”

Section: Discussionmentioning

confidence: 60%

Novel Application Method for Mesenchymal Stem Cell Therapy Utilizing Its Attractant-Responsive Accumulation Property

et al. 2019

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Stem cell therapy is an emerging treatment modality for various diseases. Because mesenchymal stem cells (MSCs) are known to accumulate at the site of damage, their possible clinical application has been investigated. MSCs are usually administered using intravenous injection, but this route carries a risk of pulmonary embolism. In contrast, topical injection of MSCs reportedly has an inferior therapeutic effect. We developed a remote administration method that uses collagen gel as a scaffold and investigated the effect of this scaffold on the retention of stemness, homing ability, and therapeutic effect using a mouse tooth extraction model. After verifying the retention of stemness of MSCs isolated from the bone marrow of donor mice in the scaffold, we administered MSCs subcutaneously into the back of the recipient mice with scaffold and observed the accumulation and the acceleration of healing of the extraction socket of the maxillary first molar. The MSCs cultured with scaffold retained stemness, the MSCs injected into back skin with scaffold successfully accumulated around the extraction socket, and socket healing was significantly enhanced. In conclusion, administration of MSCs with collagen scaffold at a remote site enhanced the lesion healing without the drawbacks of currently used administration methods.

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“…For example, Wang et al cultured neural crest stem cells derived from iPSCs on a tubular nanofibrous scaffold for sciatic nerve regeneration (Wang et al 2011). In another study, Kimura et al conducted cell transplantation by neural crest-like cells derived from human induced pluripotent stem cells (hiPSCs) and utilizing a silicon tube as a bridge for sciatic nerve regeneration (Kimura et al 2018). Okawa et al utilized the same strategy to improve diabetic neuropathy.…”

Section: Induced Pluripotent Stem Cellsmentioning

confidence: 99%

Nanomaterial integration into the scaffolding materials for nerve tissue engineering: a review

Arzaghi

Adel

Jafari

et al. 2020

Reviews in the Neurosciences

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The nervous system, which consists of a complex network of millions of neurons, is one of the most highly intricate systems in the body. This complex network is responsible for the physiological and cognitive functions of the human body. Following injuries or degenerative diseases, damage to the nervous system is overwhelming because of its complexity and its limited regeneration capacity. However, neural tissue engineering currently has some capacities for repairing nerve deficits and promoting neural regeneration, with more developments in the future. Nevertheless, controlling the guidance of stem cell proliferation and differentiation is a challenging step towards this goal. Nanomaterials have the potential for the guidance of the stem cells towards the neural lineage which can overcome the pitfalls of the classical methods since they provide a unique microenvironment that facilitates cell–matrix and cell–cell interaction, and they can manipulate the cell signaling mechanisms to control stem cells’ fate. In this article, the suitable cell sources and microenvironment cues for neuronal tissue engineering were examined. Afterward, the nanomaterials that impact stem cell proliferation and differentiation towards neuronal lineage were reviewed.

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Stem cells purified from human induced pluripotent stem cell-derived neural crest-like cells promote peripheral nerve regeneration

Cited by 44 publications

References 54 publications

Concise Review: Mesenchymal Stem Cells Derived from Human Pluripotent Cells, an Unlimited and Quality-Controllable Source for Therapeutic Applications

Concise Review: Mesenchymal Stem Cells Derived from Human Pluripotent Cells, an Unlimited and Quality-Controllable Source for Therapeutic Applications

Novel Application Method for Mesenchymal Stem Cell Therapy Utilizing Its Attractant-Responsive Accumulation Property

Nanomaterial integration into the scaffolding materials for nerve tissue engineering: a review

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