Stem cells in the treatment of chronic spinal cord injury: evaluation of somatosensitive evoked potentials in 39 patients

Cristante, Alexandre Fogaça; Filho, Tarcísio Eloy Pessoa de Barros; Tatsui, Nelson Hidekazu; Mendrone, Alfredo; Caldas, José Guilherme M.endes Pereira; Camargo, A.P.P; Alexandre, A; Teixeira, W G J; Oliveira, Reginaldo Perilo; Marcon, Raphael Martus

doi:10.1038/sc.2009.24

Cited by 87 publications

(74 citation statements)

References 25 publications

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“…Cristante и соавт [43] проводили терапию 39 пациентам с хронической травмой спинно-го мозга при помощи трансплантации МСК, выделенных из периферической крови, а за-тем введенных в сегмент спинальной травмы с помощью артериографии, используя для вве-дения по 2,5 миллиона МСК на 1 кг веса тела. Соматосенсорные вызванные потенциалы (ССВП), записанные в течение следующих 2,5 лет, показали увеличенную амплитуду у 66,7% пациентов.…”

Section: мск для терапии псмтunclassified

Cell Therapy of Stroke and Spinal Cord Injury Complications

Konoplyannikov¹,

Baklaushev²,

Kalsin³

et al. 2015

Journal of Clinical Practice

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е!ь …%" В обзоре анализируется современное состояние проблемы клеточной терапии неврологи-ческих осложнений ишемического инсульта и позвоночно-спинномозговой травмы (ПСМТ). Приводятся современные данные по использованию различных типов стволовых клеток для терапии данных тяжелых нарушений, полученные как в экспериментальных исследованиях на животных моделях, так и в результате клинических исследований. Наиболее подробно рассма-тривается применение мезенхимальных стволовых клеток (МСК) и нейральных стволовых/ прогениторных клеток (НСК/НПК) для терапии инсульта и ПСМТ. Обсуждаются дальнейшие перспективы развития клеточной терапии указанных заболеваний.Ключевые слова: ишемический инсульт, позвоночно-спинномозговая травма, стволовые клет-ки, мезенхимальные стволовые клетки, нейральные стволовые/прогениторные клетки. CELL THERAPY OF STROKE AND SPINAL CORD INJURY COMPLICATIONSThe review analyzes the current advances of cell therapy for neurological complications of ischemic stroke and spinal cord injury (SCI). We demonstrate the most recent data on the use of different types of stem cells for the treatment of these severe damages, obtained both in experimental studies using animal models and in clinical studies. We particularly discuss the use of mesenchymal stem cells (MSC) and neural stem/progenitor cells (NSC/NPC) for the treatment of stroke and SCI. We also discuss the prospects for a further development of cell therapy of these diseases.

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Section: мск для терапии псмтunclassified

Cell Therapy of Stroke and Spinal Cord Injury Complications

Konoplyannikov¹,

Baklaushev²,

Kalsin³

et al. 2015

Journal of Clinical Practice

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“…No serious complications were reported, and 30.4% of patients who received MSCs at acute and subacute stages showed significant improvements in their ASIA scale position (27). Few clinical studies have shown neurological improvements in MSC-treated patients who during the chronic stage of SCI, when the glial scar is already present (28,29,30,31,32). In these studies, MSCs were transplanted directly into the lesion intrathecally, intravenously and intrathecally (simultaneously) at once, and intraarterially.…”

Section: Mesenchymal Stem Cellsmentioning

confidence: 99%

Stem Cells: New Hope For Spinal Cord Injury

Gazdic

Volarević

Stojković

2015

Serbian Journal of Experimental and Clinical Research

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“…Amyotrophic Lateral Sclerosis: Starting with amyotrophic lateral sclerosis, the first US food and drug administration approved clinical trial for stem cell treatment of ALS was on 2014 [134].…”

Section: Ipscsmentioning

confidence: 99%

Stem Cells for Neuro-regeneration: State of the Art

Wagih¹,

Elhawary²,

Ellessy³

et al. 2015

BIO

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Neuroregeneration (NR) is a long-sought medical dream which has intrigued vast research in the past decades. A traditional physiologic dogma that central nervous system does not regenerate has been strongly challenged in the recent years since the advent of the stem cell era. Stem cell research in the regenerative field passes through three main stages. The first stage is the in-vitro experiments which studies the exact molecular and cellular mechanisms underlying stem cell-mediated NR. The second stage is the application of these data in experimental animal settings to provide "proof of concept" of stem cell therapy in animal models. The final step is the translation of these data in pilot clinical trials. In this review, we will try to gather the different data of stem cell-mediated NR from various experimental and clinical researches.

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Stem cells in the treatment of chronic spinal cord injury: evaluation of somatosensitive evoked potentials in 39 patients

Abstract: None.

Cited by 87 publications

References 25 publications

Cell Therapy of Stroke and Spinal Cord Injury Complications

Cell Therapy of Stroke and Spinal Cord Injury Complications

Stem Cells: New Hope For Spinal Cord Injury

Stem Cells for Neuro-regeneration: State of the Art

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