Stem cells in prostate cancer initiation and progression

Lawson, Devon A.; Witte, Owen N.

doi:10.1172/jci32810

Cited by 154 publications

(137 citation statements)

References 91 publications

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“…Cancer stem cells were first identified in leukemia (20,21). Recently, many investigators have identified cancer stem cells in solid tumors including breast, brain, pancreas, colon, and head and neck cancers (22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35). These new discoveries provide further support for the cancer stem cell hypothesis.…”

Section: Cancer Stem Cell Hypothesismentioning

confidence: 86%

MicroRNA Regulation of Cancer Stem Cells and Therapeutic Implications

DeSano

2009

AAPS J

143

107

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Abstract. MicroRNAs (miRNAs) are a class of endogenous non-protein-coding RNAs that function as important regulatory molecules by negatively regulating gene and protein expression via the RNA interference (RNAi) machinery. MiRNAs have been implicated to control a variety of cellular, physiological, and developmental processes. Aberrant expressions of miRNAs are connected to human diseases such as cancer. Cancer stem cells are a small subpopulation of cells identified in a variety of tumors that are capable of self-renewal and differentiation. Dysregulation of stem cell self-renewal is a likely requirement for the initiation and formation of cancer. Furthermore, cancer stem cells are a very likely cause of resistance to current cancer treatments, as well as relapse in cancer patients. Understanding the biology and pathways involved with cancer stem cells offers great promise for developing better cancer therapies, and might one day even provide a cure for cancer. Emerging evidence demonstrates that miRNAs are involved in cancer stem cell dysregulation. Recent studies also suggest that miRNAs play a critical role in carcinogenesis and oncogenesis by regulating cell proliferation and apoptosis as oncogenes or tumor suppressors, respectively. Therefore, molecularly targeted miRNA therapy could be a powerful tool to correct the cancer stem cell dysregulation.

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Section: Cancer Stem Cell Hypothesismentioning

confidence: 86%

MicroRNA Regulation of Cancer Stem Cells and Therapeutic Implications

DeSano

2009

AAPS J

143

107

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“…New approaches depend on CSC exterminating rather than total tumor decay. The limitation for these studies is to be able to specifically target CSCs in normal tissue that also contains its specific SCs; since, they have similar expressional and antigenic profiles [101]. Consequently, new markers are needed to distinguish CSCs from tissue specific SCs.…”

Section: Microrna-mediated Regulation Of Pcscsmentioning

confidence: 99%

Stem Cells and Prostate Cancer

Çetintaş¹,

Kaymaz²,

Kosova³

2013

Advances in Prostate Cancer

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“…This has been shown to effectively allow NSC proliferation in a range of species (murine 33 , canine 34 , porcine 35 , monkey 36 and human 37 ). Similarly, nonadherent, serum-poor culturing conditions have been shown to be applicable for SC in colon 38,39 , breast 40,41 , prostate 42,43 , heart 44 , skin 45,46 , pancreas 47,48 , and liver 49 . Under these conditions SC can proliferate extensively, while cells lacking this ability are eliminated.…”

Section: Definition Of Neural Stem Cellsmentioning

confidence: 99%