Stem cells in gynecology

Lane, Felicia; Jacobs, Stephanie

doi:10.1016/j.ajog.2012.01.045

Cited by 15 publications

(6 citation statements)

References 43 publications

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“…Many studies in the urogenital field have confirmed the long‐term safety of the application of mesenchyme and muscle‐derived stem cells in the treatment of urinary and anal incontinence, fistula repair and enhancement of graft material. No adverse effects were identified and we agree with the conclusion that the application of autologous regenerative cells in this field can be safe and effective .…”

Section: Discussionsupporting

confidence: 88%

A novel method for treatment of chronic anal fissure: adipose‐derived regenerative cells – a pilot study

Andjelkov¹,

Sforza²,

Barišić

et al. 2017

Colorectal Disease

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Section: Discussionsupporting

confidence: 88%

A novel method for treatment of chronic anal fissure: adipose‐derived regenerative cells – a pilot study

Andjelkov¹,

Sforza²,

Barišić

et al. 2017

Colorectal Disease

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“…The possible mechanisms of AI stem cell therapy are direct stem cell integration and muscle regeneration, the bulking effect of the cells and the carrier, the trophic effect caused by the stem cell growth factor secretion or immune modulation, and the decreased inflammation that improves tissue healing [33,57]. The bulking effect is probably not the mechanism according to our results, because there was no advantage in the bulking agent Bulkamid compared with the 0.9% NaCl-controls, and also because there were good results with hASCs in 0.9% NaCl as well.…”

Section: Discussionmentioning

confidence: 99%

Functional Outcome of Human Adipose Stem Cell Injections in Rat Anal Sphincter Acute Injury Model

Kuismanen

Juntunen

Narra

et al. 2018

Stem Cells Translational Medicine

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Anal incontinence is a devastating condition that significantly reduces the quality of life. Our aim was to evaluate the effect of human adipose stem cell (hASC) injections in a rat model for anal sphincter injury, which is the main cause of anal incontinence in humans. Furthermore, we tested if the efficacy of hASCs could be improved by combining them with polyacrylamide hydrogel carrier, Bulkamid. Human ASCs derived from a female donor were culture expanded in DMEM/F12 supplemented with human platelet lysate. Female virgin Sprague‐Dawley rats were randomized into four groups (n = 14–15/group): hASCs in saline or Bulkamid (3 × 105/60 μl) and saline or Bulkamid without cells. Anorectal manometry (ARM) was performed before anal sphincter injury, at two (n = 58) and at four weeks after (n = 33). Additionally, the anal sphincter tissue was examined by micro‐computed tomography (μCT) and the histological parameters were compared between the groups. The median resting and peak pressure during spontaneous contraction measured by ARM were significantly higher in hASC treatment groups compared with the control groups without hASCs. There was no statistical difference in functional results between the hASC‐carrier groups (saline vs. Bulkamid). No difference was detected in the sphincter muscle continuation between the groups in the histology and μCT analysis. More inflammation was discovered in the group receiving saline with hASC. The hASC injection therapy with both saline and Bulkamid is a promising nonsurgical treatment for acute anal sphincter injury. Traditional histology combined with the 3D μCT image data lends greater confidence in assessing muscle healing and continuity. Stem Cells Translational Medicine 2018;7:295–304

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“…As treatment with AASCs showed reversal of chronic inflammatory changes with healing of erosions, improved symptoms and better cervical health with improved quality of life and well-being, in long term prevention from Ca Cervix is expected. [11][12][13] AASCs are easy to obtain, do not have any immunogenic complication and ethical issues. 14,15 This treatment can reverse as well as stop further damage caused to cervix due to irritation or infection.…”

Section: Discussionmentioning

confidence: 99%

Chronic cervicitis: role of adult autologus stem cells

Jain¹,

Jain²

2017

Int J Reprod Contracept Obstet Gynecol

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Background: Stem cells are biological cells found in all multi-cellular organisms and capable to differentiate into diverse specialized cell types and self-renew to produce more stem cells. Stem cells act as immuno-modulatory, angiogenetic, cell repairing and cell protecting agents. They also have strong anti-inflammatory effect due to paracrine action of trophic factors release. Chronic cervicitis is very common disease of adult women worldwide, chronic infection and inflammation of the cervix is hard to cure with high recurrence rate leading to long term consequences like pelvic inflammatory disease, infertility, ectopic pregnancy, chronic pelvic pain, increased predisposition to HPV and HIV infection and even can be a precursor of cervical cancer.Methods: To show the therapeutic and symptomatic benefits of these cells in chronic cervicitis we injected 10 patients with adult autologus stem cells (AASCs) locally in the cervix, and PRP, growth factors IV. All the cells were harvested from bone marrow after bone marrow aspiration.Results: Clinical benefits were evident on follow up visits in the entire treated patient. All the patient had shown improvement in symptoms like continuous malodourous discharge, dyspariunea, pelvic pain and pressure, backache, itching and burning, post coital bleeding.Conclusions: Present study have shown that AASCs and growth factors is a safe effective ethical and viable option not only to cure the disease but also in improving the quality of life of a woman and protecting her from its significant consequences.

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Stem cells in gynecology

Cited by 15 publications

References 43 publications

A novel method for treatment of chronic anal fissure: adipose‐derived regenerative cells – a pilot study

A novel method for treatment of chronic anal fissure: adipose‐derived regenerative cells – a pilot study

Functional Outcome of Human Adipose Stem Cell Injections in Rat Anal Sphincter Acute Injury Model

Chronic cervicitis: role of adult autologus stem cells

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