Stem Cells in Dermatology and Anti-aging Care of the Skin

Taub, Amy Forman; Pham, Kim

doi:10.1016/j.fsc.2018.06.004

Cited by 30 publications

(21 citation statements)

References 53 publications

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“…Adult stem cells are present in the bulge region of the hair follicles and the basal layer of the interfollicular epidermis and play a critical role in maintaining the structural and functional integrity of the skin through self-renewal and generation of daughter cells that undergo terminal differentiation [ 81 ]. Skin aging is more associated with the reduction of healthy stem cells able to respond to proliferative signals rather than the reduction of the total number of stem cells [ 82 ].…”

Section: Modulation Of Cell Senescence and Epidermal Differentiation By Nicotinamidementioning

confidence: 99%

Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation

Boo

2021

Antioxidants

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Vitamin B3 (nicotinic acid, niacin) deficiency causes the systemic disease pellagra, which leads to dermatitis, diarrhea, dementia, and possibly death depending on its severity and duration. Vitamin B3 is used in the synthesis of the NAD+ family of coenzymes, contributing to cellular energy metabolism and defense systems. Although nicotinamide (niacinamide) is primarily used as a nutritional supplement for vitamin B3, its pharmaceutical and cosmeceutical uses have been extensively explored. In this review, we discuss the biological activities and cosmeceutical properties of nicotinamide in consideration of its metabolic pathways. Supplementation of nicotinamide restores cellular NAD+ pool and mitochondrial energetics, attenuates oxidative stress and inflammatory response, enhances extracellular matrix and skin barrier, and inhibits the pigmentation process in the skin. Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials. Topically applied nicotinamide is well tolerated by the skin. Currently, there is no convincing evidence that nicotinamide has specific molecular targets for controlling skin aging and pigmentation. This substance is presumed to contribute to maintaining skin homeostasis by regulating the redox status of cells along with various metabolites produced from it. Thus, it is suggested that nicotinamide will be useful as a cosmeceutical ingredient to attenuate skin aging and hyperpigmentation, especially in the elderly or patients with reduced NAD+ pool in the skin due to internal or external stressors.

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Section: Modulation Of Cell Senescence and Epidermal Differentiation By Nicotinamidementioning

confidence: 99%

Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation

Boo

2021

Antioxidants

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“…A review by Taub and Pham 34 highlighted research on the use of defensins, which are antimicrobial signaling peptides that can signal multipotent stems cells from the hair follicles to supply the epithelium in an injured state. [34][35][36] The use of stem cells and topical growth factors provides a potential localized approach to enhance soft tissue wound healing. However, more research is needed to fully determine its specific formulations, method of delivery, and applications.…”

Section: Future Promisementioning

confidence: 99%

Dermabrasion for Scars and Wire Loop Electrocautery for Rhinophyma

Hom

Harmon

2019

Facial plast Surg

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Dermabrasion and wire loop electrocautery are controlled scalpel-less procedures to remove superficial skin layers to treat dermal surface irregularities. Their postprocedure healing involves healing by secondary intention. The purpose of this paper is to discuss the use of diamond fraise dermabrasion to improve scars and the use of wire loop electrocautery to treat rhinophyma surface irregularities. Both techniques are minimally invasive and low cost, and at the same time, can significantly improve facial skin deformities. An advantage in using wire loop electrocautery for rhinophyma excision is that it is a simple, economic, and very effective technique to sculpt the nose, with minimal intraoperative bleeding. With dermabrasion, pretreatment and postregimens can help improve postprocedure results. Future efforts to modulate the healing from both of these techniques include the potential use of topical growth factors, autologous platelet-rich plasma, or using stem cells to accelerate collagen formation and reepithelization during the postprocedure period.

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“…The corollary of geroscience in the medical field is anti-aging medicine, which tries to "cure" aging by rejuvenating older individuals (Gammack and Morley, 2004;Rattan, 2004;Bartke, 2008;Balistreri, 2018). This is made by the modulation of the extrinsic attributes of aging such as wrinkled skin (e.g., by hyaluronic acid or botox injections) (Draelos, 2008;Taub and Pham, 2018) or the intrinsic attributes such as sarcopenia (by stem cell treatment) (Chhetri et al, 2018).…”

Section: Is There a Place For Anti-aging Medicine?mentioning

confidence: 99%

Are We Ill Because We Age?

et al. 2019

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Growing elderly populations, sometimes referred to as gray (or silver) tsunami, are an increasingly serious health and socioeconomic concern for modern societies. Science has made tremendous progress in the understanding of aging itself, which has helped medicine to extend life expectancies. With the increase of the life expectancy, the incidence of chronic age-related diseases (ARDs) has also increased. A new approach trying to solve this problem is the concept of geroscience. This concept implies that the aging process itself is the common cause of all ARDs. The corollary and consequence of such thinking is that we can and should treat aging itself as a disease. How to translate this into the medical practice is a big challenge, but if we consider aging as a disease the problem is solved. However, as there is no common definition of what aging is, what its causes are, why it occurs, and what should be the target(s) for interventions, it is impossible to conclude that aging is a disease. On the contrary, aging should be strongly considered not to be a disease and as such should not be treated; nonetheless, aging is likely amenable to optimization of changes/adaptations at an individual level to achieve a better functional healthspan.

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Stem Cells in Dermatology and Anti-aging Care of the Skin

Cited by 30 publications

References 53 publications

Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation

Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation

Dermabrasion for Scars and Wire Loop Electrocautery for Rhinophyma

Are We Ill Because We Age?

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