Stem Cells Derived Exosomes Vincristine Sulfate Loaded as Potential Biological Nano Carriers for Treatment of Breast Cancer Stem Cells
Ahmed H. Farouk,
Ahmed Aref,
Belal A. Fathy
et al.
Abstract:Due to vincristine sulfate's (VCR sulfate) toxicity and non-specific targeting, which might adversely damage healthy cells, its clinical application is restricted. In this study, we loaded VCR sulfate on exosomes generated from mesenchymal stem cells (MSCs) to enhance its targeted distribution. Exosomes are able to deliver molecules to specific cells and tissues and have therapeutic potential. In this study we isolated exosomes from MSCs, and using probe-sonication approach loaded them with VCR sulfate. Using … Show more
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