Stem Cells as a Promising Tool for the Restoration of Brain Neurovascular Unit and Angiogenic Orientation

Geranmayeh, Mohammad Hossein; Nourazarian, Alireza; Avci, Çığır Biray; Rahbarghazi‬, Reza; Farhoudi, Mehdi

doi:10.1007/s12035-016-0286-4

Cited by 12 publications

(9 citation statements)

References 164 publications

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“…It should be born in mind that several chemotaxis assays in vitro have shown that Dose-dependent migration of MSCs could be induced by chemokines like CCL2/MCP1 (monocyte chemoattractant protein-1), CCL25 (thymus expressed chemokine), CXCL8 (IL8), CXCL12/SDF1α and CXCL13 (BCA1) [50]. In addition, sphingosine 1 phosphate (S1P) exerted a strong chemoattraction on MSCs through matrix metalloproteinase (MMP)-mediated signaling events and the RhoA/ROCK and MEK1/ERK intracellular pathways [51].…”

Section: Recruitment Of Mscsmentioning

confidence: 99%

Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment

Elmahallawy

Mohamed

Abdo

et al. 2020

IJMS

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Hepatocellular carcinoma (HCC) is the most common hepatobiliary malignancy with limited therapeutic options. On the other hand, melatonin is an indoleamine that modulates a variety of potential therapeutic effects. In addition to its important role in the regulation of sleep–wake rhythms, several previous studies linked the biologic effects of melatonin to various substantial endocrine, neural, immune and antioxidant functions, among others. Furthermore, the effects of melatonin could be influenced through receptor dependent and receptor independent manner. Among the other numerous physiological and therapeutic effects of melatonin, controlling the survival and differentiation of mesenchymal stem cells (MSCs) has been recently discussed. Given its controversial interaction, several previous reports revealed the therapeutic potential of MSCs in controlling the hepatocellular carcinoma (HCC). Taken together, the intention of the present review is to highlight the effects of melatonin and mesenchymal stem cells as a key for functional integrity for liver cancer treatment. We hope to provide solid piece of information that may be helpful in designing novel drug targets to control HCC.

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Section: Recruitment Of Mscsmentioning

confidence: 99%

Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment

Elmahallawy

Mohamed

Abdo

et al. 2020

IJMS

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“…For example, neural or embryonic stem cells are suitable stem cell sources for CNS diseases; however, they are very sparse and extremely difficult to acquire. In contrast, bone marrow mesenchymal or hemopoietic stem cells, which have been used in many diseases, originate from a different embryo layer than the neural system, and thus, they have limited potential to differentiate into neurons [ 4 , 5 ]. Moreover, the identified stem cell sources cannot meet the substantial clinical requirements in a short time.…”

Section: Introductionmentioning

confidence: 99%

Transplanted hair follicle stem cells migrate to the penumbra and express neural markers in a rat model of cerebral ischaemia/reperfusion

et al. 2020

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Background Ischaemic stroke has become the main cause of death and severe neurological disorders, for which effective restorative treatments are currently limited. While stem cell transplantation offers therapeutic potential through neural regeneration, this approach is associated with the challenges of limited applicable sources. Hair follicle stem cells (HFSCs) are multipotential cells that can differentiate into ectodermal and mesodermal lineages and proliferate for long periods. The therapeutic potentials of HFSCs have not been investigated in ischaemic stroke models, and therefore, in this study, we aimed to determine whether they could survive and migrate to ischaemic areas after a stroke attack. Methods A rat model of middle cerebral artery ischaemia/reperfusion was established and intravenously administered HFSCs. The potential of HFSCs to migrate and differentiate into neuron-like cells as well as their ability to reduce the infarct size was evaluated. Rat brain tissue samples were collected 2 weeks after cell transplantation and analysed via TTC staining, immunofluorescence and immunohistochemistry methods. The data were statistically analysed and presented as the means ± standard deviations. Results Intravenously administrated rat HFSCs were able to migrate to the penumbra where they expressed neuron-specific markers, reduced the infarct volume and promoted neurological recovery. Conclusion HFSC transplantation has therapeutic potential for ischaemic stroke and is, therefore, worthy of further investigation toward possible clinical development for treating stroke patients.

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“…MSCs have been investigated for in vitro and in vivo experimental studies and clinical studies in various conditions due to their anti-inflammatory effects, low immunogenicity, and potential to repair damaged tissues [12][13][14]. They were also reported to have a vital role in regenerating human organs and tissues, such as bone marrow, brain, eye, intestine, lung, skin, adipose tissue, and dental pulp [15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Secretome Analysis of Inductive Signals for BM-MSC Transdifferentiation into Salivary Gland Progenitors

Mona

Kobeissy

Park

et al. 2020

IJMS

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Severe dry mouth in patients with Sjögren’s Syndrome, or radiation therapy for patients with head and neck cancer, significantly compromises their oral health and quality of life. The current clinical management of xerostomia is limited to palliative care as there are no clinically-proven treatments available. Previously, our studies demonstrated that mouse bone marrow-derived mesenchymal stem cells (mMSCs) can differentiate into salivary progenitors when co-cultured with primary salivary epithelial cells. Transcription factors that were upregulated in co-cultured mMSCs were identified concomitantly with morphological changes and the expression of acinar cell markers, such as α-amylase (AMY1), muscarinic-type-3-receptor(M3R), aquaporin-5(AQP5), and a ductal cell marker known as cytokeratin 19(CK19). In the present study, we further explored inductive molecules in the conditioned media that led to mMSC reprogramming by high-throughput liquid chromatography with tandem mass spectrometry and systems biology. Our approach identified ten differentially expressed proteins based on their putative roles in salivary gland embryogenesis and development. Additionally, systems biology analysis revealed six candidate proteins, namely insulin-like growth factor binding protein-7 (IGFBP7), cysteine-rich, angiogenetic inducer, 61(CYR61), agrin(AGRN), laminin, beta 2 (LAMB2), follistatin-like 1(FSTL1), and fibronectin 1(FN1), for their potential contribution to mMSC transdifferentiation during co-culture. To our knowledge, our study is the first in the field to identify soluble inductive molecules that drive mMSC into salivary progenitors, which crosses lineage boundaries.

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Stem Cells as a Promising Tool for the Restoration of Brain Neurovascular Unit and Angiogenic Orientation

Cited by 12 publications

References 164 publications

Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment

Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment

Transplanted hair follicle stem cells migrate to the penumbra and express neural markers in a rat model of cerebral ischaemia/reperfusion

Secretome Analysis of Inductive Signals for BM-MSC Transdifferentiation into Salivary Gland Progenitors

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