Stem cells and future periodontal regeneration

Lin, Ni‐Hung; Gronthos, Stan; Bartold, P. Mark

doi:10.1111/j.1600-0757.2009.00303.x

Cited by 114 publications

(121 citation statements)

References 162 publications

(201 reference statements)

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“…[12];  Regeneration of dental pulp (discussed below; c.f. [13]);  Regeneration of dentin based on biological approaches and potentially as biological fillers that may replace current synthetic materials for restorative dentistry [14][15][16];  Regeneration of cementum as a part of periodontium regeneration or for loss of cementum and/or dentin resulting from trauma or orthodontic tooth movement [17][18];  Regeneration of the periodontium including cementum, periodontal ligament and alveolar bone [19][20][21][22];  Regeneration or synthesis of enamel-like structures that may be used as biological substitute for lost enamel [23][24][25]. Since a tooth is a biological organ, it is unavoidable that regeneration of various components of the tooth is highly inter-connected.…”

mentioning

confidence: 99%

Tooth regeneration: a revolution in stomatology and evolution in regenerative medicine

Yıldırım

Kim

et al. 2011

Int J Oral Sci

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A tooth is a complex biological organ and consists of multiple tissues including the enamel, dentin, cementum and pulp. Tooth loss is the most common organ failure. Can a tooth be regenerated? Can adult stem cells be orchestrated to regenerate tooth structures such as the enamel, dentin, cementum and dental pulp, or even an entire tooth? If not, what are the therapeutically viable sources of stem cells for tooth regeneration? Do stem cells necessarily need to be taken out of the body, and manipulated ex vivo before they are transplanted for tooth regeneration? How can regenerated teeth be economically competitive with dental implants? Would it be possible to make regenerated teeth affordable by a large segment of the population worldwide? This review article explores existing and visionary approaches that address some of the above-mentioned questions. Tooth regeneration represents a revolution in stomatology as a shift in the paradigm from repair to regeneration: repair is by metal or artificial materials whereas regeneration is by biological restoration. Tooth regeneration is an extension of the concepts in the broad field of regenerative medicine to restore a tissue defect to its original form and function by biological substitutes.

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mentioning

confidence: 99%

Tooth regeneration: a revolution in stomatology and evolution in regenerative medicine

Yıldırım

Kim

et al. 2011

Int J Oral Sci

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“…MSCs are a group cells that have been isolated from virtually every vascularized tissue [62]. MSCs are a group cells that have been isolated from virtually every vascularized tissue [52]; however, recent reports have documented that they can also be isolated from other sources as umbilical cord [62], peripheral blood [63], adipose tissue [64][65][66][67], hair follicle [68], periodontal ligament [69][70][71][72], gingival tissue [73] and dental pulp [74,75], among others.…”

Section: Mesenchymal Stem Cells-based Therapymentioning

confidence: 99%

Regenerative Medicine: A New Paradigm in Bone Regeneration

Chaparro¹,

Linero²

2016

Advanced Techniques in Bone Regeneration

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Bone defects are the cause of functional disability and the restoration of skeletal function remains an important challenge on orthopedics, neurosurgery and oral and maxillofacial surgery. Because of the limitations of the currently used techniques for the reconstruction of bone defects and the difficulties for the implementation of new therapeutic strategies, a new paradigm in the field of reconstructive surgery has arisen, leading to tissue engineering and regenerative medicine. Mesenchymal stem cells (MSC) have emerged as a promising alternative for the treatment of bone lesions. It was postulated that the therapeutic action was the result of proliferation and differentiation of MSCs, replacing injured tissue. However, recent studies have shown that MSCs secrete a number of trophic factors that have a strong effect during repair and tissue regeneration. This represents a shift from a paradigm centered on MSC proliferation and differentiation to a new paradigm in which the MSCs exert their beneficial effect by the secretion of paracrine factors that induce endogenous repair mechanisms. This chapter will bring together basic and clinical aspects, focused on novel findings on MSC paracrine effect and the development of new therapeutic strategies based on growth factors, cytokines and signaling molecules involved in bone regeneration.

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“…Harvesting these cells is associated with minimal donor morbidity. However, there are a few limitations associated with their application as described in Table 3 [83].…”

Section: Epithelial Cell Rests Of Malassez (Ecrm)mentioning

confidence: 99%

“…Integration of the human stem cell derivatives with the recipient tissue and their ability to carry out the desired functions in humans is still under speculation Table 3: Limitations in the application of Dental MSC for periodontal regeneration [83].…”

Section: Biological Technical Clinicalmentioning

confidence: 99%

The Scope of Stem Cells in Periodontal Regeneration

George¹

2015

JDODT

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Stem cells and future periodontal regeneration

Cited by 114 publications

References 162 publications

Tooth regeneration: a revolution in stomatology and evolution in regenerative medicine

Tooth regeneration: a revolution in stomatology and evolution in regenerative medicine

Regenerative Medicine: A New Paradigm in Bone Regeneration

The Scope of Stem Cells in Periodontal Regeneration

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