Stem Cells and Biological Approaches to Treatment of Wrist Problems

Chong, Alphonsus K.S.; He, Min

doi:10.1055/s-0033-1357761

Cited by 3 publications

(5 citation statements)

References 36 publications

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“…Moreover, the source of the graft was not specified in the meta-analysis, but the authors reported that iliac crest bone graft was more commonly used 16. Traditionally, autologous iliac crest bone grafting is a widely accepted standard for fracture nonunion management with the advantage of providing mesenchymal stem cells to the fracture site and structural support 27,28. However, there is a notable risk of infection and long-term pain at the donor site 16.…”

Section: Discussionmentioning

confidence: 99%

“…16 Traditionally, autologous iliac crest bone grafting is a widely accepted standard for fracture nonunion management with the advantage of providing mesenchymal stem cells to the fracture site and structural support. 27,28 However, there is a notable risk of infection and long-term pain at the donor site. 16 In a series of 38 scaphoid nonunions treated with iliac crest corticocancellous grafting, 8 (21%) patients reported experiencing pain when wearing a belt, and 14 (37%) reported donor site hypoesthesia.…”

Section: Discussionmentioning

confidence: 99%

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Outcomes of Pediatric Scaphoid Nonunions Treated With Distal Radius Cancellous Autograft

Lin

Grenier

Samora

2022

Journal of Pediatric Orthopaedics

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Background: The optimal management of pediatric scaphoid fracture nonunions is controversial. We hypothesize that pediatric patients with scaphoid fracture nonunions will have favorable functional outcomes with the utilization of nonvascularized distal radius cancellous autograft with open reduction and internal fixation (ORIF). Methods: A review was performed from 2012 to 2017 identifying skeletally immature patients with scaphoid fracture nonunions treated with ORIF and nonvascularized distal radius cancellous autograft, including demographic data, mechanism of injury, length of time from injury to treatment, operative procedure, length of immobilization, time to union, and complications. Results: Ten patients (9 males, 1 female) met inclusion criteria. Mean age was 14.3 SD 1.5 years. The majority of fractures were sustained during sports or secondary to a fall. Mean time between injury and orthopaedic evaluation was 33 weeks (SD 20 wk). Eight fractures occurred at the waist, and 2 occurred at the proximal pole. Four patients had a humpback deformity, and three presented with a dorsal intercalated segmental instability deformity. Nine patients were treated with a single cannulated compression screw with distal radius autograft. One patient also received a single Kirschner wire fixation in addition to a single cannulated screw and graft. Patients underwent a mean postoperative immobilization period of 14 SD 5 weeks. Two patients received a bone stimulator postoperatively. Radiographic union was documented after initial surgery in nine patients, with mean time to union of 17 SD 5 weeks. The 1 patient with persistent radiographic nonunion underwent revision fixation and repeat nonvascularized distal radius autograft, achieving union and resolution of symptoms. All patients ultimately reported full return to activity. Conclusions: Pediatric scaphoid fracture nonunions that undergo ORIF using nonvascularized distal radius cancellous autograft have favorable rates of consolidation and functional outcomes. Surgeons should consider this source of grafting in operative management of scaphoid nonunions in children and adolescents. Level of Evidence: Level IV, therapeutic.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Outcomes of Pediatric Scaphoid Nonunions Treated With Distal Radius Cancellous Autograft

Lin

Grenier

Samora

2022

Journal of Pediatric Orthopaedics

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“…MSC-based treatment is a promising strategy to improve outcomes in hand surgery via biological approach. MSC can be administrated as cell-based implantation at injured sites or as cellular component in tissue engineering-based approach [ 1 ]. MSCs are considered as the principal progenitors for bone regeneration.…”

Section: Discussionmentioning

confidence: 99%

“…In hand surgery field, current tissue engineering approach involving cell-based therapy has potential role in hand surgery such as scaphoid nonunion, avascular necrosis, cartilage injury, osteoarthritis or reconstruction of bone deformity at wrist joint [ 1 ]. Mesenchymal stem cell (MSC) is a promising cell type in orthopedics and regenerative medicine [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…We would like to access for the feasibility of isolation method and to characterize of MSC from small amount aspiration samples harvested from ulna and radius. Thus, the objectives of this study were to determine [ 1 ] in vitro growth kinetics using population doubling time (PDT) and clonogenic ability [ 2 ], immunophenotypes and [ 3 ] differentiation potential of MSCs from radius and ulna obtaining with small amount aspiration.…”

Section: Introductionmentioning

confidence: 99%

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Feasibility of bone marrow mesenchymal stem cells harvesting from forearm bone

Tawonsawatruk

Kanchanathepsak

Duangchan

et al. 2021

Heliyon

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Introduction Mesenchymal stem cell is a promising therapeutic option in orthopedic filed and regenerative medicine. The feasibility of isolation method and characterization of Mesenchymal stem cell including growth kinetics, immunophenotypes and differentiation potency from small volume aspiration harvested from ulna and radius should be evaluated in order to utilize this cell in hand surgery. Materials and methods Mesenchymal stem cells were isolated and characterized from bone marrow of 12 patients who underwent internal fixation of fractures at radius or ulna. Population doubling time & clonogenic ability, immunophenotypes and trilineage differentiation potential of Mesenchymal stem cells were evaluated. Results Mesenchymal stem cells derived from bone marrow were attached to plastic flasks and became homogenous monolayer of fibroblast-like cells. They exhibited clonogenic ability and demonstrated positive markers which were shown by CD 73, CD 90, and CD 105 and negative markers which were shown by CD 34, CD 45. Mesenchymal stem cells derived from this source were capable of osteogenesis, chondrogenesis and adipogenesis. Discussion This study demonstrated the feasibility of bone marrow mesenchymal stem cells harvested from forearm bone marrow with small volume samples. This source should be useful in tissue engineering strategy or orthobiologic approach in orthopedic surgery.

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