Stem cell treatment for acute myocardial infarction

Abstract

Despite the high degree of heterogeneity observed, the results of this systematic review suggest that moderate improvement in global heart function is significant and sustained long-term. However, because mortality rates after successful revascularization of the culprit arteries are very low, larger number of participants would be required to assess the full clinical effect of this treatment. Standardisation of methodology, cell dosing and cell product formulation, timing of cell transplantation and patient selection may also be required in order to reduce the substantial heterogeneity observed among the included studies.

Are Selected Bone Marrow Stem Cells More Effective than Unselected Ones in Patients with Chronic Myocardial Infarction?

“…However, the magnitudes of the improvement were greater with echocardiography than with MRI. This finding was consistent with one of the previous meta-analyses of stem cell treatment for patients with acute myocardial infarction [19].…”

Are Selected Bone Marrow Stem Cells More Effective than Unselected Ones in Patients with Chronic Myocardial Infarction?

“…However, the magnitudes of the improvement were greater with echocardiography than with MRI. This finding was consistent with one of the previous meta-analyses of stem cell treatment for patients with acute myocardial infarction [19].…”

Inhibition of Gap Junction Formation Prior to Implantation of Bone Marrow-Derived Mesenchymal Cells Improves Function in the Ischemic Myocardium

“…Furthermore, the elapsed time following injection and analysis of surviving BM-MSCs (24 h) may not have been of a sufficient length to detect significant differences in retention between the CBX-treated and untreated BM-MSCs. It is noteworthy, however, that the number of CBX-treated BM-MSCs retained in the ischemic/reperfused hearts was sufficient to enhance cardiac function and is consistent with earlier studies reported by Clifford that the number of MSCs used in clinical trials is directly proportional to their effect on cardiac function [10].…”

Long-Term Effects of Autologous Bone Marrow Stem Cell Treatment in Acute Myocardial Infarction: Factors That May Influence Outcomes

“…The present study was designed: (i) to assess potential risks of bias and diversity amongst different randomised trials to address major limitations in the field and (ii) to evaluate what factors may influence the long-term effect of BMSC treatment. This meta-analysis confirms the findings of our previous study [4] that BMSC treatment moderately improves heart function and has as yet not been associated with any significant safety concerns, but does not decrease mortality or morbidity significantly in long-term follow-up (with the caveat that there have been no studies designed to address mortality). Our power calculation estimates that a trial with several thousand participants would be needed to detect significant differences in mortality between treatment and control groups.…”

Are Selected Bone Marrow Stem Cells More Effective than Unselected Ones in Patients with Chronic Myocardial Infarction?

“…However, the magnitudes of the improvement were greater with echocardiography than with MRI. This finding was consistent with one of the previous meta-analyses of stem cell treatment for patients with acute myocardial infarction [19].…”

Inhibition of Gap Junction Formation Prior to Implantation of Bone Marrow-Derived Mesenchymal Cells Improves Function in the Ischemic Myocardium

“…Furthermore, the elapsed time following injection and analysis of surviving BM-MSCs (24 h) may not have been of a sufficient length to detect significant differences in retention between the CBX-treated and untreated BM-MSCs. It is noteworthy, however, that the number of CBX-treated BM-MSCs retained in the ischemic/reperfused hearts was sufficient to enhance cardiac function and is consistent with earlier studies reported by Clifford that the number of MSCs used in clinical trials is directly proportional to their effect on cardiac function [10].…”

Long-Term Effects of Autologous Bone Marrow Stem Cell Treatment in Acute Myocardial Infarction: Factors That May Influence Outcomes

“…The present study was designed: (i) to assess potential risks of bias and diversity amongst different randomised trials to address major limitations in the field and (ii) to evaluate what factors may influence the long-term effect of BMSC treatment. This meta-analysis confirms the findings of our previous study [4] that BMSC treatment moderately improves heart function and has as yet not been associated with any significant safety concerns, but does not decrease mortality or morbidity significantly in long-term follow-up (with the caveat that there have been no studies designed to address mortality). Our power calculation estimates that a trial with several thousand participants would be needed to detect significant differences in mortality between treatment and control groups.…”

Are Selected Bone Marrow Stem Cells More Effective than Unselected Ones in Patients with Chronic Myocardial Infarction?

“…However, the magnitudes of the improvement were greater with echocardiography than with MRI. This finding was consistent with one of the previous meta-analyses of stem cell treatment for patients with acute myocardial infarction [19].…”

Inhibition of Gap Junction Formation Prior to Implantation of Bone Marrow-Derived Mesenchymal Cells Improves Function in the Ischemic Myocardium

“…Furthermore, the elapsed time following injection and analysis of surviving BM-MSCs (24 h) may not have been of a sufficient length to detect significant differences in retention between the CBX-treated and untreated BM-MSCs. It is noteworthy, however, that the number of CBX-treated BM-MSCs retained in the ischemic/reperfused hearts was sufficient to enhance cardiac function and is consistent with earlier studies reported by Clifford that the number of MSCs used in clinical trials is directly proportional to their effect on cardiac function [10].…”

Long-Term Effects of Autologous Bone Marrow Stem Cell Treatment in Acute Myocardial Infarction: Factors That May Influence Outcomes

“…The present study was designed: (i) to assess potential risks of bias and diversity amongst different randomised trials to address major limitations in the field and (ii) to evaluate what factors may influence the long-term effect of BMSC treatment. This meta-analysis confirms the findings of our previous study [4] that BMSC treatment moderately improves heart function and has as yet not been associated with any significant safety concerns, but does not decrease mortality or morbidity significantly in long-term follow-up (with the caveat that there have been no studies designed to address mortality). Our power calculation estimates that a trial with several thousand participants would be needed to detect significant differences in mortality between treatment and control groups.…”