Stem cell therapy in Alzheimer’s disease: possible benefits and limiting drawbacks

Alipour, Masoume; Nabavi, Seyed Massood; Arab, Leila; Vosough, Massoud; Pakdaman, Hossein; Ehsani, Ehsan; Shahpasand, Koorosh

doi:10.1007/s11033-018-4499-7

Cited by 65 publications

(50 citation statements)

References 140 publications

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“…Moreover, using nanomaterials in combination with stem cells could introduce several applications in brain regenerative studies (Alipour et al 2018). Nanomaterials provide an ideal platform for enhancing the efficacy of stem cell treatment (Misra et al 2016), imaging and tracking of stem cells (Sibov et al 2014), implying genetic modifications to mediate stem cell proliferation and differentiation (Tiwari et al 2013), and improving neuronal differentiation of stem cells into neurons (Stephanopoulos et al 2014).…”

Section: Future Directions Of Stem Cell-based Therapy Against Admentioning

confidence: 99%

Stem cells as a promising therapeutic approach for Alzheimer’s disease: a review

Fouad

2019

Bull Natl Res Cent

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Alzheimer's disease (AD) is a neurodegenerative disorder that impairs memory formation and disrupts neurocognitive function. This neuropathy is characterized by neural loss, neurodegeneration, and formation of amyloid plaques and neurofibrillary tangles. Approved medications provide only symptomatic relief without affecting AD progression. Because of the multifactorial nature of AD and the absence of effective treatment, stem cell-based therapy has been regarded as an effective, safe, and innovative therapeutic approach to overcome AD. Different sources of stem cells are employed for AD treatment, such as neural stem cells (NSCs), mesenchymal stem cells (MSCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs). There is a growing body of evidence supporting the promising therapeutic potential of stem cell transplantation, which might be attributed to the mechanistic actions exerted by stem cells such as inducing hippocampal neurogenesis, secreting paracrine factors, exerting anti-inflammatory activity, showing anti-amyloidogenic potential, and finally resulting in cognitive recovery. Although stem cell-based therapy faces potential hurdles, it holds a potential hope to provide a safe, effective, and feasible clinical application of stem cells in AD patients.

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Section: Future Directions Of Stem Cell-based Therapy Against Admentioning

confidence: 99%

Stem cells as a promising therapeutic approach for Alzheimer’s disease: a review

Fouad

2019

Bull Natl Res Cent

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“…They are classified as embryonic and adult according to their origin. Since the first embryonic stem cell growth in culture medium in 1998, experimental studies and investigations related to stem cell treatment have been conducted on many neurological degenerative disorders mainly spinal cord injuries, cerebral infarct, Parkinson disease, AD (83)(84)(85)(86)(87)(88)(89)(90)(91). Mainly two stem cell types are used: pluripotent stem cell/induced pluripotent stem cell originated from embryonic stem cell, and adult stem cells (neuronal stem cells, hematopoietic stem cells, mesenchymal stem cells).…”

Section: Discussionmentioning

confidence: 99%

“…It was designated that neural stem cells decreased with age; hippocampal neurogenesis rate was slowed down with age; and there was progressive and diffuse cell death in these areas in AD (89). It was indicated that endogenous neural stem cells were regulated by various chemical agents and growth factors (89,90). In recent years, studies about prevention of death of neurons and glial cells, produced by the stem cells by the stimulation and regulation of primarily endogenous neural stem cells, have been performed (89,90).…”

Section: Discussionmentioning

confidence: 99%

“…It was indicated that endogenous neural stem cells were regulated by various chemical agents and growth factors (89,90). In recent years, studies about prevention of death of neurons and glial cells, produced by the stem cells by the stimulation and regulation of primarily endogenous neural stem cells, have been performed (89,90). It is a known fact that in case of damage, endogenous neural stem cells prevent apoptosis in damaged cells by producing and secreting various trophic factors (90).…”

Section: Discussionmentioning

confidence: 99%

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Improvement of Spatial Learning and Memory Impairments by Fetal Neural Tissue Transplantation in Experimental Rat Model of Alzheimer’s Disease

Can¹,

Barlas²

2019

BMB

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It is known that the acetylcholinergic afferents of the neocortex from subcortical areas participate in learning and memory. Autopsy studies in cases of Alzheimer's disease (AD) have shown that most of the neurons of nucleus basalis magnocellularis (NBM) are atrophic or decreased in number. In this study, we searched for whether or not it was possible to improve the impaired learning and memory functions with foetal neural tissue transplantation in an experimental model of AD. Method: A total of thirty seven young adult male Wistar albino rats were served as experimental subjects. NBM on the right side was destroyed by the injection of kainic acid stereotactically so as to make a model of AD. The grafts were obtained from 14-16 day foetuses of the same genus. After the tissue with cholinergic neurons dissected from ventral forebrain and tissue with non-cholinergic neurons dissected from telencephalic vesicle, cell suspensions were prepared and injected stereotactically to the ipsilateral frontal cortex. Spatial learning and memory functions were tested by Morris' water maze tasks. Results: Spatial learning and memory functions in rats were impaired by unilateral lesions of nucleus basalis magnocellularis. The impairment observed during the early period partially improved by the time. It was observed that this amelioration was accelerated with both cholinergic and non-cholinergic foetal neural tissue implantation. Amaç: Subkortikal alanlardan neokortekse uzanan asetilkolinerjik nöronların öğrenme ve bellek süreçlerinde rol aldığı bilinmektedir. Alzheimer hastalığında (AH) yapılan otopsi incelemeleri bazal magnoselüler çekirdekteki nöronlarda atrofi veya azalma olduğunu göstermiştir. Bu çalışmada deneysel AH modelinde bozuk öğrenme ve bellek fonksiyonlarının, fötal nöral doku transplantasyonu ile düzelmesinin mümkün olup olmadığı araştırıldı. Yöntem: Deneysel çalışmada 37 adet Wistar albino cinsi genç erişkin erkek sıçan kullanıldı. AH modeli sağ bazal magnoselüler çekirdeğe stereotaktik yöntemle verilen, nörotoksik bir ajan olan kainik asit ile oluşturuldu. Greftler aynı cins sıçanların 14-16 günlük fetuslarından alındı. Kolinerjik nöronları içeren doku ventral ön beyinden, non-kolinerjik nöronların olduğu doku ise telensefalik vezikülden elde edilerek, hücre süspansiyonu haline getirildi ve stereotaktik yöntemle ipsilateral frontal kortekse implante edildi. Hacimsel öğrenme ve bellek fonksiyonları Morris'in "water maze" testi ile değerlendirildi. Bulgular: Tek taraflı bazal magnoselüler nükleus lezyonları ile sıçanlarda hacimsel öğrenme ve bellek fonksiyonları bozuldu. Erken dönemde bozulan bu fonksiyonlar geç dönemde kısmen düzeldi. Hem kolinerjik hem de non-kolinerjik fötal doku implantasyonu ile bu düzelmenin hızlandığı saptandı.

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“…Furthermore, they can differentiate into neurons, astrocytes and oligodendrocytes (4). nSc transplantation may be an effective method to cure neurodegenerative diseases by repairing and replenishing functional neurons (5,6). Several studies have revealed that transplanting nSc can alleviate the learning and memory impairment in an ad mouse model (7,8).…”

Section: Introductionmentioning

confidence: 99%

Neural stem cell transplantation improves learning and memory by protecting cholinergic neurons and restoring synaptic impairment in an amyloid precursor protein/presenilin 1 transgenic mouse model of Alzheimer's disease

Zhu

Zhang

et al. 2020

Mol Med Report

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alzheimer's disease (ad) is the most prevalent age-related neurodegenerative disorder. it is featured by the progressive accumulation of β-amyloid (aβ) plaques and neurofibrillary tangles. This can eventually lead to a decrease of cholinergic neurons in the basal forebrain. Stem cell transplantation is an effective treatment for neurodegenerative diseases. Previous studies have revealed that different types of stem or progenitor cells can mitigate cognition impairment in different alzheimer's disease mouse models. However, understanding the underlying mechanisms of neural stem cell (nSc) therapies for ad requires further investigation. in the present study, the effects and the underlying mechanisms of the treatment of ad by nScs are reported. The latter were labelled with the enhanced green fluorescent protein (EGFP) prior to implantation into the bilateral hippocampus of an amyloid precursor protein (aPP)/presenilin 1 (PS1) transgenic (Tg) mouse model of ad. it was observed that the number of basal forebrain cholinergic neurons was restored and the expression of choline acetyltransferase (chaT) protein was increased. Moreover, the levels of synaptophysin (SYP), postsynaptic density protein 95 (PSd-95) and microtubule-associated protein (MaP-2) were significantly increased in the hippocampus of NSC-treated ad mice. notably, spatial learning and memory were both improved after transplantation of nScs. in conclusion, the present study revealed that nSc transplantation improved learning and memory functions in an ad mouse model. This treatment allowed repairing of basal forebrain cholinergic neurons and increased the expression of the cognition-related proteins SYP, PSd-95 and MaP-2 in the hippocampus.

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Stem cell therapy in Alzheimer’s disease: possible benefits and limiting drawbacks

Cited by 65 publications

References 140 publications

Stem cells as a promising therapeutic approach for Alzheimer’s disease: a review

Stem cells as a promising therapeutic approach for Alzheimer’s disease: a review

Improvement of Spatial Learning and Memory Impairments by Fetal Neural Tissue Transplantation in Experimental Rat Model of Alzheimer’s Disease

Neural stem cell transplantation improves learning and memory by protecting cholinergic neurons and restoring synaptic impairment in an amyloid precursor protein/presenilin 1 transgenic mouse model of Alzheimer's disease

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